灰黄霉素酸，一种环磷酸腺苷磷酸二酯酶抑制剂及其酯类：提高细胞内环磷酸腺苷水平并降低眼压。 - Suppr | 超能文献

Griseolic acid, a cAMP phosphodiesterase inhibitor, and its ester: increase in cellular cAMP levels and reduction of intraocular pressure.

作者信息

Yamazaki M, Yasumoto T, Iijima Y, Yokoyama T, Fukami S, Kaneko M, Kiuchi Y, Mishima H

机构信息

Sankyo Co. Ltd., New Lead, Tokyo, Japan.

出版信息

Adv Second Messenger Phosphoprotein Res. 1990;24:502-6.

Abstract

摘要

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Griseolic acid, a cAMP phosphodiesterase inhibitor, and its ester: increase in cellular cAMP levels and reduction of intraocular pressure.灰黄霉素酸，一种环磷酸腺苷磷酸二酯酶抑制剂及其酯类：提高细胞内环磷酸腺苷水平并降低眼压。

Adv Second Messenger Phosphoprotein Res. 1990;24:502-6.

2

Effects of the new phosphodiesterase inhibitor griseolic acid on insulin release in rat pancreatic islets.新型磷酸二酯酶抑制剂灰黄酸对大鼠胰岛胰岛素释放的影响。

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3

Griseolic acid, an inhibitor of cyclic adenosine 3',5'-monophosphate phosphodiesterase. I. Taxonomy, isolation and characterization.灰黄霉素酸，一种环磷酸腺苷磷酸二酯酶抑制剂。I. 分类学、分离与特性鉴定。

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Properties of base-substituted and carboxyl-esterified analogues of griseolic acid, a potent cAMP phosphodiesterase inhibitor.灰黄酸的碱基取代和羧基酯化类似物的性质，一种有效的环磷酸腺苷磷酸二酯酶抑制剂。

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5

[Changes in ocular hypotensive effect of griseolic acid with isoproterenol, timolol and melanin].[灰黄霉素酸与异丙肾上腺素、噻吗洛尔及黑色素联合应用时眼降压作用的变化]

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A cyclic AMP phosphodiesterase inhibitor, 8'-pivaloyloxymethyl ester (POM-ester) of griseolic acid, lowers rabbit intraocular pressure.环磷酸腺苷磷酸二酯酶抑制剂，灰黄霉素酸的8'-新戊酰氧基甲酯（POM-酯）可降低兔眼压。

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7

Studies on griseolic acid derivatives. I. Synthesis of substituted derivatives of griseolic acid at the N1, C6, C2' or C7' position and their biological activities.灰黄霉酸衍生物的研究。I. N1、C6、C2'或C7'位取代的灰黄霉酸衍生物的合成及其生物活性。

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Maintenance of meiotic arrest in mouse oocytes by purines: modulation of cAMP levels and cAMP phosphodiesterase activity.嘌呤对小鼠卵母细胞减数分裂阻滞的维持作用：cAMP 水平及 cAMP 磷酸二酯酶活性的调节

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Biological properties of griseolic acid, a cyclic AMP phosphodiesterase inhibitor with an adenine group.灰黄霉素酸的生物学特性，一种带有腺嘌呤基团的环磷酸腺苷磷酸二酯酶抑制剂。

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10

Studies on griseolic acid derivatives. VII. Synthesis and phosphodiesterase inhibitory activity of the C4'-C5' hydrogenated products of griseolic acid and their base-exchanged derivatives.灰黄霉素酸衍生物的研究。VII. 灰黄霉素酸C4'-C5'氢化产物及其碱交换衍生物的合成与磷酸二酯酶抑制活性

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