Department of Pharmacology, Government Medical College, Nagpur, Maharashtra, India.
Indian J Pharmacol. 2011 May;43(3):232-5. doi: 10.4103/0253-7613.81495.
Zinc supplementation is a critical new intervention for treating diarrheal episodes in children. Recent studies suggest that administration of zinc along with new low osmolarity oral rehydration solutions / salts (ORS), can reduce the duration and severity of diarrheal episodes for up to three months. The World Health Organization (WHO) and UNICEF recommend daily 20 mg zinc supplements for 10 - 14 days for children with acute diarrhea, and 10 mg per day for infants under six months old, to curtail the severity of the episode and prevent further occurrences in the ensuing -two to three months, thereby decreasing the morbidity considerably. This article reviews the available evidence on the efficacy and safety of zinc supplementation in pediatric diarrhea and convincingly concludes that zinc supplementation has a beneficial impact on the disease outcome.
补锌是治疗儿童腹泻的一项重要新干预措施。最近的研究表明，在给予新型低渗透压口服补液盐/电解质溶液（ORS）的同时补充锌，可将腹泻持续时间和严重程度减少长达三个月。世界卫生组织（WHO）和联合国儿童基金会（UNICEF）建议急性腹泻儿童每日补锌 20 毫克，持续 10-14 天，6 个月以下婴儿每天补锌 10 毫克，以减轻腹泻严重程度，并防止随后的两到三个月内再次发生，从而大大降低发病率。本文综述了锌补充剂治疗儿科腹泻的疗效和安全性方面的现有证据，有力地证明了锌补充剂对疾病结局具有有益的影响。
