Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA.
J Autism Dev Disord. 2012 May;42(5):827-36. doi: 10.1007/s10803-011-1314-x.
The goal of this investigation was to examine plasma amino acid (AA) levels in children with Autism Spectrum Disorders (ASD, N = 27) and neuro-typically developing controls (N = 20). We observed reduced plasma levels of most polar neutral AA and leucine in children with ASD. This AA profile conferred significant post hoc power for discriminating children with ASD from healthy children. Furthermore, statistical correlations suggested the lack of a typical decrease of glutamate and aspartate with age, and a non-typical increase of isoleucine and lysine with age in the ASD group. Findings from this limited prospective study warrant further examination of plasma AA levels in larger cross-sectional and longitudinal cohorts to adequately assess for relationships with developmental and clinical features of ASD.
本研究旨在检测自闭症谱系障碍（ASD，N=27）儿童与神经典型发育对照（N=20）儿童的血浆氨基酸（AA）水平。我们观察到 ASD 儿童的大多数极性中性 AA 和亮氨酸的血浆水平降低。这种 AA 谱赋予了区分 ASD 儿童和健康儿童的重要事后功效。此外，统计相关性表明，ASD 组缺乏谷氨酸和天冬氨酸随年龄典型下降，以及异亮氨酸和赖氨酸随年龄非典型增加。这项有限的前瞻性研究的结果需要在更大的横断面和纵向队列中进一步检查血浆 AA 水平，以充分评估其与 ASD 的发育和临床特征的关系。
