Zamani Ali, Shariat Mamak, Oloomi Yazdi Zohreh, Bahremand Shahla, Akbari Asbagh Parvin, Dejakam Afshin
Department of Pediatrics, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran.
Acta Med Iran. 2011;49(5):314-8.
Iron deficiency can cause cognitive and functional learning disorders in children. Some studies have reported a relationship between low serum ferritin levels in patients with anemia and Helicobacter pylori (H. pylori) infection. Therefore, we aimed to determine the relationship between these two common diseases. This descriptive analytical cross-sectional study was performed to assess serum ferritin levels and H. pylori antibody titers (IgG) among 6-12 year old healthy primary school children in Tehran during the academic year 2005-2006. Specimen collection was done by cluster and randomization methods (multistage sampling). Personal information and laboratory results were compiled in questionnaires and data were analyzed by descriptive and analytical statistics via SPSS software. 165 primary school children (43% boys, 57% girls) with mean age 9.2 ± 1.5 years were enrolled in the study. H. pylori IgG antibody titer was positive in 26% of cases with mean values of 0.79 ± 0.42 units in boys and 0.75 ± 0.39 units in girls, which showed a significant statistical difference (P=0.004). H. pylori infection was more common among children of large families or those with low economic status (P=0.002). 29% of children had low serum ferritin levels. Out of the children with low serum ferritin levels, 71% and 28% had negative and positive anti H. pylori antibody titers (IgG levels), respectively. Also, 296 children (25%) with normal ferritin levels had H. pylori infection. We did not find a significant relationship between H. pylori infection and low serum ferritin levels or iron deficiency anemia.
缺铁可导致儿童出现认知和功能性学习障碍。一些研究报告了贫血患者血清铁蛋白水平低与幽门螺杆菌（H. pylori）感染之间的关系。因此，我们旨在确定这两种常见疾病之间的关系。本描述性分析横断面研究旨在评估2005 - 2006学年德黑兰6至12岁健康小学生的血清铁蛋白水平和幽门螺杆菌抗体滴度（IgG）。标本采集采用整群抽样和随机化方法（多阶段抽样）。个人信息和实验室结果录入问卷，数据通过SPSS软件进行描述性和分析性统计分析。165名小学生（43%为男孩，57%为女孩），平均年龄9.2±1.5岁，纳入本研究。26%的病例幽门螺杆菌IgG抗体滴度呈阳性，男孩平均值为0.79±0.42单位，女孩为0.75±0.39单位，差异有统计学意义（P = 0.004）。幽门螺杆菌感染在大家庭儿童或经济状况较差的儿童中更为常见（P = 0.002）。29%的儿童血清铁蛋白水平较低。在血清铁蛋白水平低的儿童中，分别有71%和28%的幽门螺杆菌抗体滴度（IgG水平）为阴性和阳性。此外，296名（25%）铁蛋白水平正常的儿童有幽门螺杆菌感染。我们未发现幽门螺杆菌感染与低血清铁蛋白水平或缺铁性贫血之间存在显著关系。
