Akcam Mustafa, Ozdem Sebahat, Yilmaz Aygen, Gultekin Meral, Artan Reha
Department of Pediatrics, Division of Pediatric Gastroenterology, Hepatology and Nutrition, Akdeniz University, Medical School, Antalya, Turkey.
Dig Dis Sci. 2007 Feb;52(2):405-10. doi: 10.1007/s10620-006-9422-8. Epub 2007 Jan 9.
We sought to explore the relationship between Helicobacter pylori infection and serum ferritin, vitamin B(12), folate, and zinc status among children. Fifty patients aged 5-18 years who underwent upper gastrointestinal endoscopy because of dyspeptic symptoms, were studied, prospectively. Patients were grouped as H. pylori positive (group 1, n=32) or H. pylori negative (group 2, n=18) by histopathologic examination and rapid urease test. Fasting serum ferritin, vitamin B(12), folate, and zinc levels of patients were measured. Both groups were indifferent according to age, gender, height standard deviation score (H(SDS)), and weight standard deviation score (W(SDS)). Serum ferritin levels were 33+/-26 and 50+/-46 ng/mL (P=.098), vitamin B(12) levels were 303+/-135 and 393+/-166 pg/mL (P=.042), folate levels were 9.64+/-3.2 and 9.61+/-2.8 ng/mL (P=.979), and zinc levels were 95+/-48 and 87+/-31 mug/dL (P=.538), in groups 1 and 2, respectively. Ferritin levels of 14 (43.8%) patients in group 1 and 6 (33.3%) patients in group 2 were below the normal range (P=.470). Serum vitamin B(12) levels of 9 children (28%) in group 1 and 2 children (11%) in group 2 were below the normal range (P=.287). The findings of the present study suggest that H. pylori infection has a negative effect on serum ferritin and vitamin B(12) levels in children. This negative effect on vitamin B(12) levels is rather marked in contrast to that on ferritin levels. H. pylori infection has no significant effect on serum folate or zinc levels among children.
我们试图探讨儿童幽门螺杆菌感染与血清铁蛋白、维生素B12、叶酸及锌水平之间的关系。对50例因消化不良症状接受上消化道内镜检查的5至18岁患者进行了前瞻性研究。通过组织病理学检查和快速尿素酶试验将患者分为幽门螺杆菌阳性组（第1组，n = 32）和幽门螺杆菌阴性组（第2组，n = 18）。测定患者空腹血清铁蛋白、维生素B12、叶酸和锌水平。两组在年龄、性别、身高标准差评分（H(SDS)）和体重标准差评分（W(SDS)）方面无差异。第1组和第2组的血清铁蛋白水平分别为33±26和50±46 ng/mL（P = 0.098），维生素B12水平分别为303±135和393±166 pg/mL（P = 0.042），叶酸水平分别为9.64±3.2和9.61±2.8 ng/mL（P = 0.979），锌水平分别为95±48和87±31 μg/dL（P = 0.538）。第1组14例（43.8%）患者和第2组6例（33.3%）患者的铁蛋白水平低于正常范围（P = 0.470）。第1组9名儿童（28%）和第2组2名儿童（11%）的血清维生素B12水平低于正常范围（P = 0.287）。本研究结果表明，幽门螺杆菌感染对儿童血清铁蛋白和维生素B12水平有负面影响。与对铁蛋白水平的影响相比，这种对维生素B12水平的负面影响更为明显。幽门螺杆菌感染对儿童血清叶酸或锌水平无显著影响。
