年轻男性的睾酮、肥胖与胰岛素抵抗：青春期性腺功能障碍与胰岛素抵抗之间关联的证据
Testosterone, obesity and insulin resistance in young males: evidence for an association between gonadal dysfunction and insulin resistance during puberty.
作者信息
Moriarty-Kelsey Megan, Harwood Jeri E F, Travers Sharon H, Zeitler Philip S, Nadeau Kristen J
机构信息
Department of Pediatrics, University of Colorado Denver/The Children's Hospital, 13123 East 16th Avenue, Aurora, CO 80045, USA.
出版信息
J Pediatr Endocrinol Metab. 2010 Dec;23(12):1281-7. doi: 10.1515/jpem.2010.202.
OBJECTIVE
To assess the relationships among obesity, insulin sensitivity, and testosterone in pubertal boys.
PARTICIPANTS
This study included 20 lean, obese, and type 2 diabetic (T2DM) males, the majority of whom underwent a hyperinsulinemic-euglycemic clamp (n=16).
METHODS
Glucose disposal (M value), serum testosterone, and body mass index (BMI) z-score were measured. Differences in testosterone were evaluated by group (lean vs. obese vs. T2DM), while regression was performed to evaluate the relationships among testosterone, obesity and insulin sensitivity.
RESULTS
Controlling for Tanner stage, testosterone concentration was significantly lower in obese (p=0.02) and T2DM males (p=0.001) compared to lean males. Furthermore, M value was significantly associated with serum testosterone, even after controlling for BMI and Tanner stage.
CONCLUSIONS
These data suggest that obese adolescent boys have lower serum testosterone than controls of the same Tanner stage, and echo the data in adult males associating obesity and insulin resistance with hypogonadism.
目的
评估青春期男孩肥胖、胰岛素敏感性和睾酮之间的关系。
参与者
本研究纳入了20名体型偏瘦、肥胖和2型糖尿病（T2DM）男性，其中大多数人接受了高胰岛素-正常血糖钳夹试验（n = 16）。
方法
测量葡萄糖处置率（M值）、血清睾酮和体重指数（BMI）z评分。按组（偏瘦组与肥胖组与T2DM组）评估睾酮差异，同时进行回归分析以评估睾酮、肥胖和胰岛素敏感性之间的关系。
结果
在控制坦纳分期后，肥胖男性（p = 0.02）和T2DM男性（p = 0.001）的睾酮浓度显著低于偏瘦男性。此外，即使在控制BMI和坦纳分期后，M值仍与血清睾酮显著相关。
结论
这些数据表明，肥胖青春期男孩的血清睾酮低于相同坦纳分期的对照组，这与成年男性中肥胖和胰岛素抵抗与性腺功能减退相关的数据相呼应。
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