Programa de Pós-graduação em Saúde da Criança e do Adolescente, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brasil.
Departamento de Ciências da Saúde, Universidade de Santa Cruz do Sul (Unisc), Santa Cruz do Sul, RS, Brasil,
Arch Endocrinol Metab. 2023 Mar 10;67(2):153-161. doi: 10.20945/2359-3997000000506. Epub 2023 Jan 17.
To set cutoff points for the triglyceride and glucose index (TyG) as a marker of insulin resistance (IR) for the pediatric population.
This was a cross-sectional study with schoolchildren population-based data using data of 377 schoolchildren age 10 to 17 years of both sexes. We studied metabolic variables associated with IR indicators, such as fasting insulin and blood glucose, to calculate the homeostatic model assessment (HOMA-IR), and we studied triglycerides (TG) to determine the TyG index. We obtained TyG cutoff values for IR using the receiver operation characteristic (ROC), with definitions of sensitivity (Sen), specificity (Spe), and area under the ROC curve (AUC), with the HOMA-IR as reference.
The cutoff points of the TyG index for IR in adolescents are 7.94 for both sexes, 7.91 for boys, and 7.94 for girls, indicating moderate discriminatory power. When we also considered anthropometric variables of excess weight [TyG-BMI (body mass index)] and visceral fat [TyG-WC (waist circumference)], these indexes reached AUC values higher than 0.72, enhancing their potential use for a good diagnosis.
TyG has proven to be a useful instrument for identifying IR in adolescent health screening, with high discrimination capacity when added to anthropometric variables, making it a feasible and inexpensive option.
为儿童人群设定甘油三酯和葡萄糖指数（TyG）作为胰岛素抵抗（IR）标志物的切点。
这是一项横断面研究，基于儿童人群的数据，共纳入了 377 名 10 至 17 岁的男女儿童。我们研究了与 IR 指标相关的代谢变量，如空腹胰岛素和血糖，以计算稳态模型评估（HOMA-IR），并研究了甘油三酯（TG）以确定 TyG 指数。我们使用接受者操作特征（ROC）获得 TyG 切点值以评估 IR，使用 HOMA-IR 作为参考，定义了敏感性（Sen）、特异性（Spe）和 ROC 曲线下面积（AUC）。
青少年 IR 的 TyG 指数切点值为男女均为 7.94，男孩为 7.91，女孩为 7.94，表明具有中等的区分能力。当我们还考虑超重的人体测量变量[TyG-BMI（体重指数）]和内脏脂肪[TyG-WC（腰围）]时，这些指数达到了 AUC 值高于 0.72，增强了其用于良好诊断的潜力。
TyG 已被证明是青少年健康筛查中识别 IR 的有用工具，当与人体测量变量结合使用时，具有较高的区分能力，是一种可行且经济的选择。
