Department of Chemistry, Duke University, Durham, North Carolina 27708, USA.
Org Lett. 2011 Aug 5;13(15):3810-3. doi: 10.1021/ol2012633. Epub 2011 Jun 29.
The first asymmetric organocatalytic sulfenylation of in situ derived nitrosoalkenes leading to chiral nonracemic α-sulfenylated ketones is described. The transformation proceeds in an umpolung fashion, relative to enolate/azaenolate methods, and uses simple thiols, thereby obviating the need for electrophilic sulfur reagents.
本文首次报道了在原位生成的亚硝烯的不对称有机催化硫代反应，得到了手性非外消旋的α-硫代酮。与烯醇盐/氮杂烯醇盐方法相比，该转化为反转极性反应，并且使用简单的硫醇，从而避免了使用亲电硫试剂。
