Department of Chemistry, Texas A&M University, P.O. Box 30012, College Station, Texas 77842-3012, USA.
J Org Chem. 2011 Aug 19;76(16):6912-7. doi: 10.1021/jo201097x. Epub 2011 Jul 12.
Phosphines are important as catalysts or reagents in synthesis but must be separated from products after a reaction. This report shows that polyisobutylene (PIB)-bound alkyldiaryl- and triarylphosphines are useful as catalysts in addition and allylic amination reactions or as reagents in aza-Wittig and Mitsunobu reactions. Heptane solutions of such phosphines and their oxidized byproducts can be easily separated from polar solutions of organic products, and PIB-phosphine oxides formed during a reaction can readily be reduced to PIB-phosphines for reuse.
膦作为催化剂或试剂在合成中很重要，但在反应后必须与产物分离。本报告表明，聚异丁烯（PIB）键合的烷基二芳基和三芳基膦在加成和烯丙基胺化反应中可用作催化剂，或在氮杂-Wittig 和 Mitsunobu 反应中用作试剂。此类膦及其氧化副产物的正庚烷溶液可以很容易地与极性有机产物溶液分离，并且反应过程中形成的 PIB-氧化膦可以很容易地还原为 PIB-膦以重复使用。
