用于溶液相化学文库合成的化学标记的光延试剂。

Chemically-tagged Mitsunobu reagents for use in solution-phase chemical library synthesis.

作者信息

Starkey G W, Parlow J J, Flynn D L

机构信息

Parallel Medicinal and Combinatorial Chemistry Unit, Searle Discovery Research Monsanto Life Sciences Company-U2E, Saint Louis, MO 63167, USA.

出版信息

Bioorg Med Chem Lett. 1998 Sep 8;8(17):2385-90. doi: 10.1016/s0960-894x(98)00431-4.

DOI:10.1016/s0960-894x(98)00431-4

PMID:9873546

Abstract

A general method for high-throughput product purification of Mitsunobu reactions is described. Tagged phosphine and azodicarboxylate reagents are used to synthesize individual library members in solution-phase. Workup and purification are easily accomplished by post-reaction sequestration of the tagged reagents and reagent byproducts by a complementary functionalized ion exchange resin. The reagents are utilized in a 3 step library synthesis.

摘要

本文描述了一种用于 Mitsunobu 反应高通量产物纯化的通用方法。使用带有标记的膦和偶氮二羧酸酯试剂在溶液相中合成各个文库成员。通过用互补的功能化离子交换树脂在反应后隔离带标记的试剂和试剂副产物，很容易完成后处理和纯化。这些试剂用于三步文库合成。