El-Gharib Mohamed Nabih, Elebyary Mona Tawfeek
Department of Obstetrics and Gynecology, Faculty of Medicine, Tanta University, Tanta, Egypt.
J Matern Fetal Neonatal Med. 2011 Oct;24(10):1239-42. doi: 10.3109/14767058.2011.561386. Epub 2011 Jun 30.
To assess the effectiveness and side effects of vaginal misoprostol (Vagiprost® tablet) termination of second and third trimester pregnancy complicated with intrauterine fetal death (IUFD).
A prospective observational cohort study.
Tanta University Hospital. Patients. The study carried out on 324 women with fetal demise in the second and third trimesters, from January 2008 to December 2009.
All patients were subjected to history taking, physical examination, and the Bishop Scoring. Application of 25 μg misoprostol in the posterior fornix of the vagina, this was repeated every 4 h over 24 h. We assessed the adverse effects, progress, and outcomes.
The success rate was 90% and 45% in women in the third and second trimesters, respectively. The mean induction-termination interval was 8.95 ± 2.63 and 15.3 ± 5.37 h for women in the third and second trimesters, respectively. The induction termination interval correlated negatively with the duration of gestation. Approximately, 90% of second trimester and 55% of third trimester women required oxytocin augmentation. The mean value of total required dose of misoprostol was 166.3 ± 7.5 and 120 ± 28.79 μg for women in the second and third trimesters, respectively.
Vagiprost appears to be a safe, effective, practical, and inexpensive method for termination of third trimester pregnancy complicated with of IUFD.
评估阴道用米索前列醇（Vagiprost®片）终止妊娠中期和晚期合并宫内死胎（IUFD）的有效性及副作用。
前瞻性观察队列研究。
坦塔大学医院。患者。本研究对2008年1月至2009年12月期间324例妊娠中期和晚期胎儿死亡的妇女进行。
所有患者均接受病史采集、体格检查及Bishop评分。将25μg米索前列醇应用于阴道后穹窿，每4小时重复一次，共24小时。我们评估了不良反应、进展及结局。
妊娠晚期和中期妇女的成功率分别为90%和45%。妊娠晚期和中期妇女的平均引产-终止间隔分别为8.95±2.63小时和15.3±5.37小时。引产-终止间隔与妊娠持续时间呈负相关。大约90%的妊娠中期妇女和55%的妊娠晚期妇女需要催产素加强宫缩。妊娠中期和晚期妇女米索前列醇总需求量的平均值分别为166.3±7.5μg和120±28.79μg。
Vagiprost似乎是一种安全、有效、实用且廉价的方法，用于终止妊娠晚期合并IUFD的妊娠。
