Department of Obstetrics & Gynaecology, Era's Lucknow Medical College, Lucknow, India.
Biosci Trends. 2010 Dec;4(6):351-4.
The present study was designed to evaluate the efficacy and safety of misoprostol (400 μg) given intravaginally repeated at 6 hourly intervals for a maximum of 6 doses for second-trimester pregnancy terminations. The study was conducted on women who had to undergo pregnancy termination between 13 and 26 weeks of gestation for various indications but mainly intrauterine death over a period of 2 years. A standard regime of 400 μg of misoprostol 6 hourly intravaginally was given until a maximum of 6 doses. Sixty women underwent second trimester terminations. The mean induction abortion interval was 11.8 h. The success rate at the end of 48 h was 96.6%. Side-effects were in the form of incomplete abortion, excessive blood loss, and fever. No patient had a uterus rupture. Intravaginal misoprostol 400 μg given 6 hourly seems to be an effective, safe, and acceptable method for second trimester pregnancy terminations.
本研究旨在评估米索前列醇（400μg）阴道内给药，每 6 小时重复一次，最多 6 剂，用于治疗 13 至 26 周妊娠的终止。这项研究是针对因各种原因需要在 2 年内进行妊娠终止的女性进行的，主要是宫内死亡。采用标准的 400μg米索前列醇阴道内每 6 小时给药方案，最多给予 6 剂。60 名女性接受了中期妊娠终止。平均诱导流产间隔为 11.8 小时。48 小时结束时的成功率为 96.6%。副作用表现为不完全流产、大量出血和发热。没有患者发生子宫破裂。阴道内给予 400μg 米索前列醇，每 6 小时一次，似乎是一种有效、安全和可接受的中期妊娠终止方法。
