Department of Family Medicine, Yonsei University Wonju College of Medicine, Republic of Korea.
Platelets. 2011;22(8):567-71. doi: 10.3109/09537104.2011.580397. Epub 2011 Jun 30.
Patients with coronary artery calcification have an increased risk of coronary vascular events and mortality. Coronary artery calcification can be quantified using the coronary calcium score (CCS) from multi-detected row computed tomography (MDCT), and the score is proportionally related to the severity of atherosclerotic disease. Mean platelet volume (MPV) is gaining interest as a new independent cardiovascular risk factor. Accordingly, the aim of our study was to evaluate the relationship between CCS and MPV in the general population. A total of 2116 individuals were enrolled from a health promotion center between July 2007 and June 2010. Among them, 259 subjects were included in the final analysis. MDCT was used to measure CCS and CCS > 1 was defined as the presence of coronary calcification. The MPV value was significantly higher in the coronary artery calcification group than in the control group. Multivariate analyses showed that MPV was positively associated with coronary calcification (OR, 1.61; 95% CI 1.02-2.55). In summary, there was a significant association between coronary artery calcification and MPV in the general population. Therefore, the detection of elevated MPV should alert clinicians to the coexistence of multiple underlying CVD risk factors warranting early evaluation and treatment.
冠状动脉钙化患者发生冠状动脉血管事件和死亡的风险增加。冠状动脉钙化可以通过多排螺旋 CT（MDCT）的冠状动脉钙化积分（CCS）来定量评估，并且该评分与动脉粥样硬化疾病的严重程度呈比例相关。平均血小板体积（MPV）作为一种新的独立心血管危险因素越来越受到关注。因此，我们的研究旨在评估一般人群中 CCS 和 MPV 之间的关系。2007 年 7 月至 2010 年 6 月期间，我们从健康促进中心共招募了 2116 名个体。其中，259 名患者被纳入最终分析。使用 MDCT 测量 CCS，CCS>1 定义为存在冠状动脉钙化。在冠状动脉钙化组中，MPV 值明显高于对照组。多变量分析显示，MPV 与冠状动脉钙化呈正相关（OR，1.61；95%CI 1.02-2.55）。总之，在一般人群中，冠状动脉钙化与 MPV 之间存在显著相关性。因此，MPV 升高的检测应提醒临床医生注意多种潜在 CVD 危险因素的共存，需要进行早期评估和治疗。
