Korkmaz Levent, Korkmaz Ayça Ata, Akyüz Ali Rıza, Ağaç Mustafa Tarık, Acar Zeydin, Kırış Abdulkadir, Kul Selim, Erkuş Muslihittin Emre, Celik Sükrü
Ahi Evren Thoracic and Vascular Surgery Training and Research Hospital, Trabzon-Turkey.
Anadolu Kardiyol Derg. 2012 Feb;12(1):35-9. doi: 10.5152/akd.2012.007. Epub 2012 Jan 4.
Platelets have an important role in the pathogenesis of atherothrombosis. It has been shown that platelet size measured by mean platelet volume (MPV), correlates with their reactivity and is still regarded as an easy, useful tool for indirect monitoring of platelet activity in different situations. Coronary artery calcification (CAC) has long been known to occur as a part of the atherosclerotic process. The aim of this study was to determine whether an association exists between MPV and CAC.
In this observational study, we enrolled 259 participants with at least one cardiac risk factor but with unknown cardiovascular disease. Coronary calcification was assessed by multislice computerized tomography and MPV was measured in a blood sample collected in EDTA tubes. Statistical analysis was performed using Kruskal-Wallis, Chi-square, correlation tests and multiple regression analysis.
Calcium scores ranged from 0 to 735. There was a significant relation between CAC and MPV (r=0.24, p=0.02), age (r=0.32, p<0.001), hypertension (r=0.19, p=0.03), diabetes (r=0.16, p=0.005), smoking (r=0.17, p=0.001). In linear regression analysis, MPV (β=0.4, 95%CI 19.8- 31.1, p<0.001), age (β=0.13, 95%CI 0.23-2.4, p=0.01) and smoking (β=0.12, 95%CI 3.2-15.1, p=0.02) independently associated with CAC. In addition, there were significant differences in MPV between significant CAC group compared to the minimal and none (10.2 ± 2.4 versus 8.1 ± 0.9 and 7.6 ± 1.3; p<0.001).
We have found significant association between MPV and CAC. Although this study is purely correlative and no causative conclusions can be drawn, it may suggest that higher MPV may reflect increased atherosclerotic burden and cardiovascular risk.
血小板在动脉粥样硬化血栓形成的发病机制中起重要作用。研究表明，通过平均血小板体积（MPV）测量的血小板大小与其反应性相关，并且仍然被视为在不同情况下间接监测血小板活性的一种简单、有用的工具。长期以来，冠状动脉钙化（CAC）一直被认为是动脉粥样硬化过程的一部分。本研究的目的是确定MPV与CAC之间是否存在关联。
在这项观察性研究中，我们纳入了259名至少有一个心脏危险因素但心血管疾病情况未知的参与者。通过多层计算机断层扫描评估冠状动脉钙化，并在采集于乙二胺四乙酸（EDTA）管中的血样中测量MPV。使用Kruskal-Wallis检验、卡方检验、相关性检验和多元回归分析进行统计分析。
钙化积分范围为0至735。CAC与MPV（r = 0.24，p = 0.02）、年龄（r = 0.32，p < 0.001）、高血压（r = 0.19，p = 0.03）、糖尿病（r = 0.16，p = 0.005）、吸烟（r = 0.17，p = 0.001）之间存在显著相关性。在线性回归分析中，MPV（β = 0.4，95%CI 19.8 - 31.1，p < 0.001）、年龄（β = 0.13，95%CI 0.23 - 2.4，p = 0.01）和吸烟（β = 0.12，95%CI 3.2 - 15.1，p = 0.02）与CAC独立相关。此外，与轻度钙化组和无钙化组相比，显著钙化组的MPV存在显著差异（10.2 ± 2.4 对比 8.1 ± 0.9 和 7.6 ± 1.3；p < 0.001）。
我们发现MPV与CAC之间存在显著关联。尽管本研究纯粹是相关性的，无法得出因果结论，但这可能表明较高的MPV可能反映动脉粥样硬化负担增加和心血管风险升高。
