College of Food Science and Nutritional Engineering, China Agricultural University, Beijing, China.
Drug Chem Toxicol. 2011 Oct;34(4):359-68. doi: 10.3109/01480545.2010.542465. Epub 2011 Jun 30.
Transgenic cloned animals expressing beneficial human nutritional traits offer a new strategy for large-scale production of some kinds of functional substances. In some cases, the required safety testing for genetically modified (GM) foods do not seem appropriate for human food safety, though regulations do not seem to provide alternatives. A 90-day rat feeding study is the core study for the safety assessment of GM foods. The test material in this 90-day study was prepared nonfat milk powder containing recombinant human lactoferrin (rhLF), which was expressed in transgenic cloned cattle. Groups of 10 male and female Sprague-Dawley rats were given a nutritionally balanced purified diet containing 7.5, 15, or 30% transgenic or conventional milk powder for 90 days. A commercial AIN93G diet was used as an additional control group. Clinical, biological, and pathological parameters were compared between groups. The only significant effect of treatment was higher mean ferritin and Fe(+) concentrations for both male and female rats fed the transgenic milk powder diets, as compared to rats fed nontransgenic milk diets or the commercial diet. The results of the present study are consistent with previous research, which indicates that milk powder containing rhLF derived from healthy transgenic cloned cattle is as safe as conventional milk powder.
转基因为人类带来营养性状的克隆动物为某些功能性物质的大规模生产提供了新的策略。在某些情况下，对于转基因（GM）食品所需的安全测试似乎并不适用于人类食品安全，尽管法规似乎没有提供替代方案。90 天大鼠喂养研究是 GM 食品安全性评估的核心研究。本 90 天研究中的测试材料是含有重组人乳铁蛋白（rhLF）的脱脂乳粉，rhLF 在转基因克隆牛中表达。10 只雄性和雌性 Sprague-Dawley 大鼠分为 3 组，每组 10 只，分别喂食含有 7.5%、15%或 30%转基因或传统乳粉的营养平衡的纯化饮食，为期 90 天。商业 AIN93G 饮食作为附加对照组。在各组之间比较临床、生物学和病理学参数。与喂食非转基因乳粉饮食或商业饮食的大鼠相比，雄性和雌性大鼠喂食转基因乳粉饮食的唯一显著影响是铁蛋白和 Fe(+)浓度较高。本研究的结果与之前的研究一致，表明来自健康转基因克隆牛的含 rhLF 的乳粉与传统乳粉一样安全。
