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白细胞介素-1α 在顺铂诱导的小鼠急性肾衰竭中的作用。

Role of IL-1α in cisplatin-induced acute renal failure in mice.

机构信息

Department of Internal Medicine, Chung-Ang University College of Medicine, Seoul, Korea.

出版信息

Korean J Intern Med. 2011 Jun;26(2):187-94. doi: 10.3904/kjim.2011.26.2.187. Epub 2011 Jun 1.

DOI:10.3904/kjim.2011.26.2.187
PMID:21716595
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3110851/
Abstract

BACKGROUND/AIMS: For unknown reasons, caspase-1 -/- mice, protected against cisplatin-induced acute renal failure (ARF), are deficient in interleukin (IL)-1α. We thus asked whether IL-1α deficiency underlies the mechanism of protection against cisplatin-induced ARF in these mice.

METHODS

Cisplatin (30 mg/kg) was injected intraperitoneally into wild-type C57BL/6 mice to produce a cisplatin-induced model of ARF. IL-1α was measured in control vehicle- and cisplatin-treated wild-type animals. We also examined whether IL-1α -/- mice were similarly protected against cisplatin-induced ARF. Additionally, infiltration of CD11b- and CD49b-positive cells, as markers of macrophages, natural killer, and natural killer T cells (pan-NK cells), was investigated in wild-type and IL-1α -/- mice.

RESULTS

Compared with vehicle-treated mice, renal IL-1α increased in cisplatin-treated wild-type mice beginning on day 1. IL-1α -/- mice were shown to be protected against cisplatin-induced ARF. No significant difference in the infiltration of neutrophils or CD11b- and CD49b-positive cells were observed between wild-type and IL-1α -/- mice.

CONCLUSIONS

Mice deficient in IL-1α are protected against cisplatin-induced ARF. The lack of IL-1α may explain, at least in part, the protection against cisplatin-induced ARF observed in caspase-1 -/- mice. Investigation of the protective mechanism (s) in IL-1α -/- mice in cisplatin-induced ARF merits further study.

摘要

背景/目的：由于未知原因， caspase-1 -/- 小鼠对顺铂诱导的急性肾衰竭（ARF）有保护作用，其白细胞介素（IL）-1α 缺乏。因此，我们想知道 IL-1α 缺乏是否是这些小鼠对顺铂诱导的 ARF 保护作用的机制。

方法

将顺铂（30mg/kg）腹膜内注射到野生型 C57BL/6 小鼠中，以产生顺铂诱导的 ARF 模型。在对照载体和顺铂处理的野生型动物中测量 IL-1α。我们还检查了 IL-1α -/- 小鼠是否对顺铂诱导的 ARF 具有相似的保护作用。此外，还研究了 CD11b 和 CD49b 阳性细胞（作为巨噬细胞、自然杀伤细胞和自然杀伤 T 细胞（pan-NK 细胞）的标志物）在野生型和 IL-1α -/- 小鼠中的浸润情况。

结果

与载体处理的小鼠相比，顺铂处理的野生型小鼠的肾脏 IL-1α 从第 1 天开始增加。IL-1α -/- 小鼠对顺铂诱导的 ARF 有保护作用。在野生型和 IL-1α -/- 小鼠之间，中性粒细胞或 CD11b 和 CD49b 阳性细胞的浸润没有明显差异。

结论

IL-1α 缺乏的小鼠对顺铂诱导的 ARF 有保护作用。缺乏 IL-1α 至少可以部分解释 caspase-1 -/- 小鼠中观察到的对顺铂诱导的 ARF 的保护作用。进一步研究 IL-1α -/- 小鼠在顺铂诱导的 ARF 中的保护机制（s）是值得的。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f0a9/3110851/771378d0ae37/kjim-26-187-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f0a9/3110851/3aab31830475/kjim-26-187-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f0a9/3110851/4631e5672a32/kjim-26-187-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f0a9/3110851/c43d03d89021/kjim-26-187-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f0a9/3110851/bc0c49089998/kjim-26-187-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f0a9/3110851/8b3ea1ed0b22/kjim-26-187-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f0a9/3110851/15ce822413d2/kjim-26-187-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f0a9/3110851/771378d0ae37/kjim-26-187-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f0a9/3110851/3aab31830475/kjim-26-187-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f0a9/3110851/4631e5672a32/kjim-26-187-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f0a9/3110851/c43d03d89021/kjim-26-187-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f0a9/3110851/bc0c49089998/kjim-26-187-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f0a9/3110851/8b3ea1ed0b22/kjim-26-187-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f0a9/3110851/15ce822413d2/kjim-26-187-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f0a9/3110851/771378d0ae37/kjim-26-187-g007.jpg

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