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通过富含鸟嘌呤的异四链体形成 PNA 探针识别 DNA 四链体靶标的动力学区分。

Kinetic discrimination in recognition of DNA quadruplex targets by guanine-rich heteroquadruplex-forming PNA probes.

机构信息

Department of Chemistry and Center for Nucleic Acids Science and Technology, Carnegie Mellon University, 4400 Fifth Avenue, Pittsburgh, PA 15213, USA.

出版信息

Chem Commun (Camb). 2011 Aug 14;47(30):8524-6. doi: 10.1039/c1cc12805a. Epub 2011 Jun 30.

DOI:10.1039/c1cc12805a
PMID:21717030
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3163151/
Abstract

Guanine-rich peptide nucleic acid probes hybridize to DNA G quadruplex targets with high affinity, forming PNA-DNA heteroquadruplexes. We report a surprising degree of kinetic discrimination for PNA heteroquadruplex formation with a series of DNA targets. The fastest hybridization is observed for targets folded into parallel morphologies.

摘要

富含鸟嘌呤的肽核酸探针与 DNA G 四链体靶标具有高亲和力，形成 PNA-DNA 异四链体。我们报道了一系列 DNA 靶标对 PNA 异四链体形成的惊人程度的动力学区分。对于折叠成平行构象的靶标，观察到最快的杂交。

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本文引用的文献

1
Loop and backbone modifications of peptide nucleic acid improve g-quadruplex binding selectivity.肽核酸的环和骨架修饰可提高与 G-四链体的结合选择性。
J Am Chem Soc. 2009 Dec 30;131(51):18415-24. doi: 10.1021/ja907250j.
2
Hybridization of short complementary PNAs to G-quadruplex forming oligonucleotides: An electrospray mass spectrometry study.短互补肽核酸与形成G-四链体的寡核苷酸的杂交：一项电喷雾质谱研究。
Biopolymers. 2009 Apr;91(4):244-55. doi: 10.1002/bip.21124.
3
Combining G-quadruplex targeting motifs on a single peptide nucleic acid scaffold: a hybrid (3+1) PNA-DNA bimolecular quadruplex.在单个肽核酸支架上结合G-四链体靶向基序：一种杂合（3+1）肽核酸-脱氧核糖核酸双分子四链体
Chemistry. 2008;14(28):8682-9. doi: 10.1002/chem.200800605.
4
The proximal promoter region of the human vascular endothelial growth factor gene has a G-quadruplex structure that can be targeted by G-quadruplex-interactive agents.人类血管内皮生长因子基因的近端启动子区域具有一种G-四链体结构，该结构可被G-四链体相互作用剂靶向作用。
Mol Cancer Ther. 2008 Apr;7(4):880-9. doi: 10.1158/1535-7163.MCT-07-2119.
5
A sequence-independent study of the influence of short loop lengths on the stability and topology of intramolecular DNA G-quadruplexes.一项关于短环长度对分子内DNA G-四链体稳定性和拓扑结构影响的非序列依赖性研究。
Biochemistry. 2008 Jan 15;47(2):689-97. doi: 10.1021/bi701873c. Epub 2007 Dec 20.
6
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Biochemistry. 2007 Sep 18;46(37):10433-43. doi: 10.1021/bi700854r. Epub 2007 Aug 24.
7
Human telomere quadruplex: refolding and selection of individual conformers via RNA/DNA chimeric editing.人类端粒四链体：通过RNA/DNA嵌合编辑对单个构象异构体进行重折叠和筛选
Biochemistry. 2007 Jun 26;46(25):7599-606. doi: 10.1021/bi602392u. Epub 2007 Jun 1.
8
Structure of an unprecedented G-quadruplex scaffold in the human c-kit promoter.人类c-kit启动子中一种前所未有的G-四链体支架结构。
J Am Chem Soc. 2007 Apr 11;129(14):4386-92. doi: 10.1021/ja068739h. Epub 2007 Mar 16.
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10
G-quadruplexes in promoters throughout the human genome.人类基因组中启动子区域的G-四链体
Nucleic Acids Res. 2007;35(2):406-13. doi: 10.1093/nar/gkl1057. Epub 2006 Dec 14.