淋巴管浸润对可切除胃癌生存的影响。
Impact of lymphatic vessel invasion on survival in curative resected gastric cancer.
机构信息
Department of Oncology, Xiangya Hospital, Central South University, No.87 Xiangya Road, 410008, Changsha, Hunan Province, China.
出版信息
J Gastrointest Surg. 2011 Sep;15(9):1526-31. doi: 10.1007/s11605-011-1600-0. Epub 2011 Jun 30.
BACKGROUND
Lymphatic vessel invasion (LV) has been regarded as a prognostic factor in some solid tumors. The aim was to clarify the impact of lymphatic vessel invasion on survival in curative resected gastric cancer.
METHODS
In this retrospective study, we reviewed the records of 1,024 patients who underwent curative resection for gastric cancer. Among all of the studied patients, 285 of them (27.8%) had lymphatic vessel invasion.
RESULTS
There were significant differences in tumor size, tumor location, depth of invasion, and lymph node metastasis (LN) between the patients with lymphatic vessel invasion and those without. The 5-year survival rates in patients were 80.1%, 59.2%, 40.9%, and 30.5% for LN-LV-, LN-LV+, LN+LV-, and LN+LV+ group, respectively. Multivariate analysis revealed that age, tumor location, the depth of invasion, and lymph node metastasis were independent prognostic factors for curative resected gastric cancer. Lymphatic vessel invasion was not an independent prognostic factor in node-positive gastric cancer; however, it was true in node-negative gastric cancer.
CONCLUSION
Lymphatic vessel invasion is one of the independent prognostic factors for node-negative gastric cancer after curative resection.
背景
淋巴管浸润（LV）已被认为是某些实体瘤的预后因素。本研究旨在阐明淋巴管浸润对可切除胃癌患者生存的影响。
方法
本回顾性研究共纳入 1024 例接受根治性胃癌切除术的患者。在所有研究患者中，285 例（27.8%）存在淋巴管浸润。
结果
淋巴管浸润患者与无淋巴管浸润患者在肿瘤大小、肿瘤位置、浸润深度和淋巴结转移（LN）方面存在显著差异。LN-LV-、LN-LV+、LN+LV-和 LN+LV+组的 5 年生存率分别为 80.1%、59.2%、40.9%和 30.5%。多因素分析显示，年龄、肿瘤位置、浸润深度和淋巴结转移是可切除胃癌的独立预后因素。淋巴管浸润不是淋巴结阳性胃癌的独立预后因素，但在淋巴结阴性胃癌中是独立的预后因素。
结论
淋巴管浸润是可切除淋巴结阴性胃癌的独立预后因素之一。
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