Bao Y
Zhonghua Yi Xue Za Zhi. 1990 Jul;70(7):382-5, 28.
The dynamic changes of myocardial beta, alpha 1-adrenergic and muscarinic cholinergic receptors (beta AR, alpha 1AR, MAchR) were investigated in endotoxic rats by radiolabelled ligand binding assay. It was found that the number of beta AR increased, while its affinity decreased progressively following endotoxin injection. The number of alpha 1AR reduced significantly during the whole course of the experiment but no change was found in its affinity. The affinity of MAchR was not changed and the number of MAchR reduced only at agonal stage. The up regulation of beta AR in early stage might indicate a compensatory mechanism, while the attenuation in affinity of beta AR and/or the number of alpha 1AR might result in the decreased responsiveness of heart to catecholamine stimulation. Since the affinity of beta AR reduced prominently at the agonal stage, the up regulation of beta AR seemed to be discompensated. The down regulation of MAchR at agonal stage of endotoxic rats might share some light of its compensatory action to the discompromised relationship between the adrenergic and cholinergic system sbut it seemed to be with no effect, which might correlate with myocardial failure.
采用放射性配体结合分析法，研究内毒素血症大鼠心肌β、α1 - 肾上腺素能和毒蕈碱胆碱能受体（βAR、α1AR、MAchR）的动态变化。结果发现，注射内毒素后，βAR数量增加，但其亲和力逐渐降低。在整个实验过程中，α1AR数量显著减少，但其亲和力未发生变化。MAchR的亲和力没有改变，仅在濒死期MAchR数量减少。早期βAR上调可能提示一种代偿机制，而βAR亲和力降低和/或α1AR数量减少可能导致心脏对儿茶酚胺刺激的反应性降低。由于濒死期βAR亲和力显著降低，βAR上调似乎失代偿。内毒素血症大鼠濒死期MAchR下调可能对肾上腺素能和胆碱能系统之间受损的关系有一定代偿作用，但似乎无效，这可能与心肌衰竭有关。
