Department of Nuclear Medicine, Rambam Health Care Campus and Rappaport School of Medicine, Technion, Israel Institute of Technology, Haifa, Israel.
Ann N Y Acad Sci. 2011 Jun;1228:150-66. doi: 10.1111/j.1749-6632.2011.06026.x.
New aggressive pathogens are responsible for the increasing incidence and difficult management of infections. Modern epidemics such as diabetes are frequently complicated by severe infections with subsequent high morbidity. Diagnosis (essentially early detection of infection) and also management decision making pose clinical challenges. Many resources are invested in developing precise, noninvasive diagnostic tests and efficient therapies for infectious processes. Nuclear medicine procedures are part of the evaluation armamentarium of patients with suspected or confirmed infection. Their strength relies on the fact that they are noninvasive tests that provide both functional as well as metabolic information early in the course of disease. Their limitations relate to the need for specific radiotracers and the rather low resolution of images. These limitations have been largely overcome by the hybrid PET/CT and SPECT/CT technology. PET/CT, primarily using FDG, is redefining the diagnostic work up and is currently leading to changes in the management of patients with suspected or known infections. The main indications for FDG PET/CT in infection, as well as updated literature results, are presented in the following review.
新的侵袭性病原体导致感染的发病率不断上升且难以控制。现代流行病如糖尿病常因严重感染而复杂化，继而导致高发病率。诊断（主要是感染的早期发现）和管理决策都带来了临床挑战。许多资源都投入到开发精确的、非侵入性的诊断检测和有效的传染病治疗方法中。核医学程序是疑似或确诊感染患者评估工具的一部分。其优势在于它们是非侵入性的测试，可以在疾病早期提供功能和代谢信息。其局限性在于需要特定的放射性示踪剂和相对较低的图像分辨率。这些局限性在很大程度上已被混合 PET/CT 和 SPECT/CT 技术克服。PET/CT 主要使用 FDG，正在重新定义诊断程序，并导致对疑似或已知感染患者的管理发生变化。本文综述了 FDG PET/CT 在感染中的主要适应证及最新文献结果。
