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用于药物递送和诊疗应用的氧化锌纳米结构

ZnO Nanostructures for Drug Delivery and Theranostic Applications.

作者信息

Martínez-Carmona Marina, Gun'ko Yurii, Vallet-Regí María

机构信息

School of Chemistry and CRANN, Trinity College, The University of Dublin, Dublin 2, Ireland.

Department Chemistry in Pharmaceutical Sciences, School of Pharmacy , Universidad Complutense de Madrid, Instituto de Investigación Sanitaria Hospital 12 de Octubre i+12, 28040 Madrid, Spain.

出版信息

Nanomaterials (Basel). 2018 Apr 23;8(4):268. doi: 10.3390/nano8040268.

Abstract

In the last two decades, zinc oxide (ZnO) semiconductor Quantum dots (QDs) have been shown to have fantastic luminescent properties, which together with their low-cost, low-toxicity and biocompatibility have turned these nanomaterials into one of the main candidates for bio-imaging. The discovery of other desirable traits such as their ability to produce destructive reactive oxygen species (ROS), high catalytic efficiency, strong adsorption capability and high isoelectric point, also make them promising nanomaterials for therapeutic and diagnostic functions. Herein, we review the recent progress on the use of ZnO based nanoplatforms in drug delivery and theranostic in several diseases such as bacterial infection and cancer.

摘要

在过去二十年中,氧化锌(ZnO)半导体量子点(QDs)已被证明具有出色的发光特性,再加上其低成本、低毒性和生物相容性,这些纳米材料已成为生物成像的主要候选材料之一。其他理想特性的发现,如它们产生破坏性活性氧(ROS)的能力、高催化效率、强吸附能力和高表面等电点,也使它们成为用于治疗和诊断功能的有前景的纳米材料。在此,我们综述了基于ZnO的纳米平台在细菌感染和癌症等几种疾病的药物递送和治疗诊断方面的最新进展。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7dee/5923598/103ad80cfbe1/nanomaterials-08-00268-g001.jpg

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