Wills C
Department of Biology, University of California, San Diego, La Jolla.
Crit Rev Biochem Mol Biol. 1990;25(4):245-80. doi: 10.3109/10409239009090611.
This review briefly surveys the literature on the nature, regulation, genetics, and molecular biology of the major energy-yielding pathways in yeasts, with emphasis on Saccharomyces cerevisiae. While sugar metabolism has received the lion's share of attention from workers in this field because of its bearing on the production of ethanol and other metabolites, more attention is now being paid to ethanol metabolism and the regulation of aerobic metabolism by fermentable and nonfermentable substrates. The utility of yeast as a highly manipulable organism and the discovery that yeast metabolic pathways are subject to the same types of control as those of higher cells open up many opportunities in such diverse areas as molecular evolution and cancer research.
本综述简要概述了有关酵母中主要能量产生途径的性质、调控、遗传学和分子生物学的文献，重点是酿酒酵母。由于糖代谢与乙醇和其他代谢产物的生产相关，因此在该领域受到了研究人员的极大关注，但现在人们更多地关注乙醇代谢以及可发酵和不可发酵底物对有氧代谢的调控。酵母作为一种易于操作的生物体的实用性，以及酵母代谢途径与高等细胞的代谢途径受到相同类型控制的发现，为分子进化和癌症研究等不同领域带来了许多机会。
