Division of Cardiothoracic Surgery, Department of Surgery, Pulmonary and Critical Care Medicine, David Geffen School of Medicine at University of California-Los Angeles, Los Angeles, California 90095, USA.
Ann Thorac Surg. 2011 Jul;92(1):303-8. doi: 10.1016/j.athoracsur.2011.04.021.
Coronary artery disease (CAD) remains a relative contraindication to lung transplantation. We have offered lung transplantation and coronary revascularization to selected patients with discrete CAD and preserved left ventricular function. The purpose of this report is the following: (1) to examine the short-term and medium-term outcome of patients after coronary revascularization and lung transplantation; and (2) to compare the short-term and medium-term outcome of this cohort to a matched group of lung transplant recipients without CAD.
From January 2000 to March 2010, 27 patients with CAD underwent coronary revascularization and lung transplantation. The control group was matched based on age, diagnosis, lung allocation score, and type of procedure.
Lung transplant recipients with CAD and the control group had similar incidence of primary graft dysfunction (grade III). The duration of mechanical ventilation, intensive care unit stay, and hospital stay were the same. At a mean follow-up of 3 years, the incidence of composite adverse cardiac events was similar in the 2 groups.
Lung transplant recipients with CAD and the control group also had similar medium-term survival. Lung transplantation can be considered in patients with preexistent CAD with acceptable early and medium-term outcomes.
冠心病（CAD）仍然是肺移植的相对禁忌证。我们已经为有明确 CAD 和左心室功能保留的患者提供了肺移植和冠状动脉血运重建。本报告的目的如下：（1）检查冠状动脉血运重建和肺移植后患者的短期和中期结果；（2）将这一组与无 CAD 的肺移植受者的匹配组进行短期和中期结果比较。
从 2000 年 1 月至 2010 年 3 月，27 例 CAD 患者接受了冠状动脉血运重建和肺移植。对照组基于年龄、诊断、肺分配评分和手术类型进行匹配。
CAD 肺移植受者和对照组的原发性移植物功能障碍（III 级）发生率相似。机械通气时间、重症监护病房住院时间和住院时间相同。在平均 3 年的随访中，两组复合不良心脏事件的发生率相似。
CAD 肺移植受者和对照组的中期生存率也相似。肺移植可以考虑用于有可接受的早期和中期结果的 CAD 患者。
Zotero 插件