Gedevanishvili M D, Gogitidze N M
Eksp Onkol. 1990;12(5):29-32.
Sensitivity to phenylephrine, isoproterenol, serotonin, oxytocin, acetylcholine and barium chloride of vas deferens uterus und fundus strip was studied comparatively in hepatectomized and sarcoma-45, sarcoma-M1, Walker carcinosarcoma and Zajdela ascites hepatoma bearing rats. The contractile response to monoamines and oxytocin was considerably lower or absent at certain periods after hepatectomy or tumour grafting. Effects of biogenic amine antagonists were also substantially altered. The response to isoproterenol, acetylcholine and barium chloride remained unchanged. Apparently a selective alteration of a response of visceral smooth muscles mediated through alpha-adrenergic and D-serotonin receptors occurred not only during the tumour growth but also in the case of active (extensive) proliferation of the normal tissue.
在肝切除大鼠以及接种了肉瘤 - 45、肉瘤 - M1、沃克癌肉瘤和扎伊德拉萨腹水肝癌的大鼠中，对苯肾上腺素、异丙肾上腺素、5 - 羟色胺、催产素、乙酰胆碱和氯化钡作用于输精管、子宫及子宫底条带的敏感性进行了比较研究。在肝切除或肿瘤移植后的某些时期，对单胺类物质和催产素的收缩反应显著降低或消失。生物胺拮抗剂的作用也发生了实质性改变。对异丙肾上腺素、乙酰胆碱和氯化钡的反应保持不变。显然，通过α - 肾上腺素能和D - 5 - 羟色胺受体介导的内脏平滑肌反应的选择性改变不仅发生在肿瘤生长期间，而且在正常组织活跃（广泛）增殖的情况下也会发生。
