Gebevanishvili M D, Gogitidze N M, Sulakvelidze M T
Patol Fiziol Eksp Ter. 1990 Sep-Oct(5):19-21.
Similar distortion of hypertensive response to epinephrine occurred in sarcoma-45-bearing rats, Walker carcinosarcoma-bearing rats, and hepatectomized rats. The response in the last-named was distorted on the 3rd postoperative day. The hypertensive response to epinephrine was restored after the regenerative processes in the liver were completed (7th-10th postoperative day). Distortion of the response in carcinosarcoma-bearing rats was detected beginning from the 4th day after transplantation in some of the animals and on the 14th day in the others; in all sarcoma 45-bearing rats distortion occurred by the 20th day. The pressor response was distorted usually under conditions of pharmacological block of the alpha-adrenergic receptors. It is assumed that in extensive proliferation of normal and neoplastic cells, substances exerting a selective blocking effect on the alpha-adrenoceptors of the blood vessels penetrate into circulation.
患有肉瘤-45的大鼠、携带沃克癌肉瘤的大鼠和肝切除大鼠对肾上腺素的高血压反应出现了类似的扭曲。肝切除大鼠在术后第3天反应出现扭曲。在肝脏再生过程完成后（术后第7 - 10天），对肾上腺素的高血压反应恢复。在一些携带癌肉瘤的大鼠中，移植后第4天开始检测到反应扭曲，其他大鼠则在第14天检测到；在所有患有肉瘤45的大鼠中，到第20天反应都出现了扭曲。升压反应通常在α-肾上腺素能受体的药理学阻断条件下发生扭曲。据推测，在正常细胞和肿瘤细胞大量增殖时，对血管α-肾上腺素能受体具有选择性阻断作用的物质会进入循环。
