[用（90）Y标记微球进行放射性栓塞：用轫致辐射单光子发射计算机断层扫描进行治疗后疗效验证]
[Radioembolization with (90)Y-labeled microspheres: post-therapeutic therapy validation with Bremsstrahlung-SPECT].
作者信息
Grober Oliver S, Nultsch Madeleine, Laatz Kathleen, Ulrich Gerd, Seidensticker Ricarda, Pethe Annette, Dudeck Oliver, Pech Maciej, Knoop Bernd O, Ricke Jens, Amthauer Holger, Geworski Lilli
机构信息
Klinik für Radiologie und Nuklearmedizin, Universitätsklinikum Magdeburg A.ö.R, Otto-von-Guericke-Universität, Deutschland.
出版信息
Z Med Phys. 2011 Dec;21(4):274-80. doi: 10.1016/j.zemedi.2011.05.002. Epub 2011 Jun 29.
During the last years angiographic Selective Internal Radiotherapy (SIRT) with (90)Y-labelled microspheres has become a common technique for the local-ablative treatment of cancer patients. SIRT is a palliative therapy concept for the treatment of liver malignancies. As a result of (90)Y-decay as β(-)-emitter without a concomitant gamma radiation, Bremsstrahlung imaging is needed to validate the distribution achieved by radioembolisation. This article demonstrates the method of imaging through phantom measurement and shows the advantages of post-therapeutic tomography by means of a patient study. Approaches for further optimization of Bremsstrahlung imaging are discussed.
在过去几年中，使用（90）Y标记微球的血管造影选择性体内放射疗法（SIRT）已成为癌症患者局部消融治疗的常用技术。SIRT是一种用于治疗肝脏恶性肿瘤的姑息治疗概念。由于（90）Y作为β（-）发射体衰变且无伴随γ辐射，因此需要通过轫致辐射成像来验证放射性栓塞所实现的分布。本文通过体模测量展示了成像方法，并通过一项患者研究展示了治疗后断层扫描的优势。还讨论了进一步优化轫致辐射成像的方法。
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