Barat Maxime, Cottereau Anne-Ségolène, Kedra Alice, Dermine Solène, Palmieri Lola-Jade, Coriat Romain, Dautry Raphael, Tselikas Lambros, Soyer Philippe, Dohan Anthony
Department of Radiology, Cochin Hospital, AP-HP, 27 rue du Faubourg Saint- Jacques, 75014 Paris, France.
Université de Paris, 75006 Paris, France.
J Clin Med. 2020 Jul 20;9(7):2302. doi: 10.3390/jcm9072302.
Interventional radiology plays an important role in the management of patients with neuroendocrine tumor liver metastasis (NELM). Transarterial embolization (TAE), transarterial chemoembolization (TACE), and selective internal radiation therapy (SIRT) are intra-arterial therapies available for these patients in order to improve symptoms and overall survival. These treatment options are proposed in patients with NELM not responding to systemic therapies and without extrahepatic progression. Currently, available data suggest that TAE should be preferred to TACE in patients with NELM from extrapancreatic origin because of similar efficacy and better patient tolerance. TACE is more effective in patients with pancreatic NELM and SIRT has shown promising results along with good tolerance. However, large randomized controlled trials are still lacking in this setting. Available literature mainly consists in small sample size and retrospective studies with important technical heterogeneity. The purpose of this review is to provide an updated overview of the currently reported endovascular interventional radiology procedures that are used for the treatment of NELM.
介入放射学在神经内分泌肿瘤肝转移（NELM）患者的管理中发挥着重要作用。经动脉栓塞（TAE）、经动脉化疗栓塞（TACE）和选择性内放射治疗（SIRT）是可用于这些患者的动脉内治疗方法，以改善症状和提高总生存率。这些治疗方案适用于对全身治疗无反应且无肝外进展的NELM患者。目前，现有数据表明，对于来自胰腺外起源的NELM患者，由于疗效相似且患者耐受性更好，TAE应优先于TACE。TACE对胰腺NELM患者更有效，SIRT已显示出有前景的结果且耐受性良好。然而，在这种情况下仍缺乏大型随机对照试验。现有文献主要包括小样本量和具有重要技术异质性的回顾性研究。本综述的目的是提供目前报道的用于治疗NELM的血管内介入放射学程序的最新概述。
