甲状旁腺激素对易卒中型自发性高血压大鼠的长期降压作用。
Long-term hypotensive effect of parathyroid hormone in stroke prone spontaneously hypertensive rats.
作者信息
Neuser D, Schulte-Brinkmann R, Knorr A, Kazda S
机构信息
Bayer AG, Department of Pharmacology, Pharma Research Center, Wuppertal 1, F.R.G.
出版信息
Eur J Pharmacol. 1990 Jul 17;182(3):569-71. doi: 10.1016/0014-2999(90)90057-d.
The influence of long-term treatment with parathyroid hormone (PTH) on blood pressure (BP) development in stroke prone spontaneously hypertensive rats (SHR/SP) was investigated. Acute i.v. administration of PTH decreased BP dose dependently. Long-term treatment of SHR/SP with 300 IU PTH s.c. per day clearly attenuated the BP increase. Treatment with PTH was associated with marked hypercalcemia, increased urinary excretion of calcium and cAMP.
研究了甲状旁腺激素（PTH）长期治疗对易卒中型自发性高血压大鼠（SHR/SP）血压（BP）发展的影响。急性静脉注射PTH可使血压剂量依赖性降低。每天皮下注射300 IU PTH对SHR/SP进行长期治疗可明显减弱血压升高。PTH治疗与明显的高钙血症、钙和环磷酸腺苷（cAMP）尿排泄增加有关。
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