[A neuropharmacological analysis of ketamine analgesia during the central stimulation of alpha 2-adrenoreceptors].

The experiments on albino rats showed that clofeline administered in a subanalgesic dose significantly potentiates the analgesic effect of ketamine at the segmental and suprasegmental levels mainly through mu-opiate and partially through beta 2-adrenergic chains. The initiating role in potentiation belongs to the activation of alpha 2-adrenoreceptors. The analgesic effect of ketamine at the segmental and suprasegmental levels is implemented through alpha 2-adrenergic apparatus and at the suprasegmental level is additionally of naloxone-depended character. The clinical trials showed that a preliminary administration of clofeline during postoperative analgesia with ketamine potentiates and prolongs the analgesic action of the latter.