一氧化碳中毒的病理生物化学
Pathobiochemistry of CO poisoning.
作者信息
Young L J, Caughey W S
机构信息
Department of Biochemistry, Duke University Medical Center, Durham, NC.
出版信息
FEBS Lett. 1990 Oct 15;272(1-2):1-6. doi: 10.1016/0014-5793(90)80436-m.
PMID:2172009
Abstract
A hypothesis for the pathobiochemical mechanism of CO poisoning, amenable to in vivo testing with optical reflectance spectrophotometry, is presented. It differs from the classical formulation in which loss of cytochrome c oxidase function is attributed entirely to O2 depletion, by including ligation and oxygenation of CO as essential components of the inhibitory process.
摘要
本文提出了一种一氧化碳中毒病理生化机制的假说，该假说适用于用光学反射分光光度法进行体内测试。它与经典理论不同，经典理论认为细胞色素c氧化酶功能的丧失完全归因于氧气耗竭，而本假说将一氧化碳的结合和氧化作为抑制过程的重要组成部分。
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