Iio Kumiko, Okada Yumika, Ishikura Masaharu
Life Science Institute, Yamaha Motor Co., Ltd.
Shokuhin Eiseigaku Zasshi. 2011;52(3):190-3. doi: 10.3358/shokueishi.52.190.
Fucoxanthin-containing oil extracted from microalga, Chaetoseros sp., was subjected to genotoxicity studies, the bacterial reverse mutation test and the micronucleus test in mice. The number of revertant colonies in fucoxanthin oil-treated plates of all strains tested was less than twice the number of colonies in the negative control, regardless of the presence of the metabolic activator in the bacterial reverse mutation test. In the micronucleus test, 500, 1,000, 2,000 mg/kg body weight of fucoxanthin oil was administered orally to mice. There was no significant increase in micronucleus frequency in bone marrow cells. These results suggest that fucoxanthin oil does not exhibit genotoxicity.
从微藻Chaetoseros sp.中提取的含岩藻黄质的油进行了遗传毒性研究、细菌回复突变试验和小鼠微核试验。在细菌回复突变试验中，无论是否存在代谢活化剂，所有受试菌株经岩藻黄质油处理的平板上回复菌落的数量均少于阴性对照菌落数量的两倍。在微核试验中，给小鼠口服500、1000、2000mg/kg体重的岩藻黄质油。骨髓细胞中的微核频率没有显著增加。这些结果表明岩藻黄质油不具有遗传毒性。
