Iio Kumiko, Okada Yumika, Ishikura Masaharu
Life Science Institute, Yamaha Motor Co., Ltd.
Shokuhin Eiseigaku Zasshi. 2011;52(3):183-9. doi: 10.3358/shokueishi.52.183.
Single oral dose and 13-week oral subchronic toxicity studies of fucoxanthin-containing oil extracted from microalga, Chaetoseros sp., were conducted in rats. In the single oral dose study, no mortality and no change related to the test material were observed. Thus, the 50% lethal dose of microalgal fucoxanthin oil is more than 2,000 mg/kg body weight. In the 13-week oral dose study, 0, 20 or 200 mg/kg body weight of microalgal fucoxanthin oil was administered. The fucoxanthin-administered groups, showed no mortality and no abnormalities. This result suggested that the no-observed-adverse-effect level of fucoxanthin-containing oil extracted from microalga Chaetoseros sp. was 200 mg/kg body weight under the tested subchronic dose condition.
对从微藻Chaetoseros sp.中提取的含岩藻黄质的油进行了大鼠单次口服剂量和13周口服亚慢性毒性研究。在单次口服剂量研究中，未观察到死亡情况，也未观察到与受试物相关的变化。因此，微藻岩藻黄质油的半数致死剂量超过2000mg/kg体重。在13周口服剂量研究中，给予0、20或200mg/kg体重的微藻岩藻黄质油。给予岩藻黄质的组未出现死亡和异常情况。该结果表明，在受试亚慢性剂量条件下，从微藻Chaetoseros sp.中提取的含岩藻黄质的油的未观察到有害作用水平为200mg/kg体重。
