The biological activity of retinoids in melanoma cells. Induction of expression of retinoic acid receptor-beta by retinoic acid in S91 melanoma cells.
作者信息
Redfern C P, Daly A K, Latham J A, Todd C
机构信息
Department of Dermatology, Medical School, University of Newcastle upon Tyne, UK.
出版信息
FEBS Lett. 1990 Oct 29;273(1-2):19-22. doi: 10.1016/0014-5793(90)81041-l.
PMID:2172028
Abstract
The expression of mRNA for retinoic acid receptor beta (RAR-beta) was induced by all trans-retinoic acid in murine S91 melanoma cells. The induction of RAR-beta was dose-dependent, rapid and insensitive to cycloheximide. Both 13-cis-retinoic acid and 3,4-didehydro-all trans-retinoic acid also induced expression of RAR-beta but were only effective at concentrations 100-fold greater than all trans-retinoic acid. The expression of RAR-alpha and RAR-gamma was unaffected by retinoic acid.
摘要
Zotero 插件