University of California at San Diego, Department of Electrical and Computer Engineering, 9500 Gilman Drive, Mail Code 0407, La Jolla, California 92092, USA.
J Biomed Opt. 2011 Jun;16(6):067002. doi: 10.1117/1.3583575.
Ultrasound microbubbles are contrast agents used for diagnostic ultrasound imaging and as carriers for noninvasive payload delivery. Understanding the acoustic properties of individual microbubble formulations is important for optimizing the ultrasound imaging parameters for improved image contrast and efficient payload delivery. We report here a practical and simple optical tool for direct real-time characterization of ultrasound contrast microbubble dynamics based on light scattering. Fourier transforms of raw linear and nonlinear acoustic oscillations, and microbubble cavitations are directly recorded. Further, the power of this tool is demonstrated by comparing clinically relevant microbubble cycle-to-cycle dynamics and their corresponding Fourier transforms.
超声微泡是用于诊断性超声成像的造影剂，也是非侵入性有效载荷传递的载体。了解单个微泡制剂的声学特性对于优化超声成像参数以提高图像对比度和有效载荷传递效率非常重要。本文报道了一种基于光散射的实用且简单的光学工具，用于直接实时表征超声造影微泡动力学。直接记录原始线性和非线性声振荡以及微泡空化的傅里叶变换。进一步通过比较临床相关的微泡循环到循环动力学及其相应的傅里叶变换，证明了该工具的强大功能。
