Key Laboratory of Modern Acoustics of Nanjing University, Ministry of Education, Nanjing, Jiangsu 210093, People's Republic of China.
J Acoust Soc Am. 2009 Dec;126(6):2954-62. doi: 10.1121/1.3242346.
Experiments were performed to measure the dynamical response of individual SonoVue microbubbles subjected to pulsed ultrasound. Three commonly used bubble dynamic models (i.e., Hoff's, Sarkar's, and linearized Marmottant's models) were compared to determine the most appropriate model for fitting to the experimental data. The models were evaluated against published optical microscopy data. The comparison suggests that it is difficult to rank these models for lipid-shelled microbubbles undergoing small-amplitude oscillations, because under these conditions the shell parameters in these models are closely related. A linearized version of the Marmottant model was used to estimate the shell parameters (i.e., shear modulus and shear viscosity) of SonoVue microbubbles from the experimental light scattering data, as a function of ambient microbubble radius. The SonoVue microbubble shell elasticity and dilatational viscosity increase with ambient bubble radius, in agreement with previously published data. The results suggest that light scattering, used in conjunction with one of several popular bubble dynamics models, is effective at characterizing microbubble response and evaluating shell parameters.
实验旨在测量单个 SonoVue 微泡在脉冲超声下的动力响应。比较了三种常用的气泡动力学模型（即 Hoff 模型、Sarkar 模型和线性 Marmottant 模型），以确定最适合拟合实验数据的模型。将模型与已发表的光学显微镜数据进行了比较。比较表明，对于经历小振幅振荡的脂质壳微泡，很难对这些模型进行排序，因为在这些条件下，这些模型中的壳参数密切相关。线性化的 Marmottant 模型用于根据实验光散射数据来估计 SonoVue 微泡的壳参数（即剪切模量和剪切粘度），作为环境微泡半径的函数。SonoVue 微泡壳的弹性和膨胀粘度随环境泡半径的增加而增加，与先前发表的数据一致。结果表明，光散射与几种流行的气泡动力学模型之一结合使用，可以有效地描述微泡的响应并评估壳参数。
