振幅整合脑电图在伴有和不伴有支气管肺发育不良的早产儿中的差异：一项横断面研究。

Amplitude-integrated EEG differences in premature infants with and without bronchopulmonary dysplasia: a cross-sectional study.

机构信息

Department of Pediatrics, Women & Infants Hospital of Rhode Island, Warren Alpert Medical School of Brown University, Providence, USA.

出版信息

Acta Paediatr. 2011 Nov;100(11):1437-41. doi: 10.1111/j.1651-2227.2011.02393.x. Epub 2011 Jul 23.

DOI:10.1111/j.1651-2227.2011.02393.x

PMID:21722174

Abstract

AIM

To evaluate differences in amplitude-integrated electroencephalogram (aEEG) recordings of infants with and without bronchopulmonary dysplasia (BPD).

METHODS

This is a cross-sectional study of infants ≤27 weeks at birth who did (n = 17) or did not develop BPD (n = 17). aEEG tracings were recorded at 36(0) -36(6) weeks post-menstrual age for 6 h using the BrainZ BRM3 monitor. A cross-cerebral channel was evaluated using offline software Analyze (BrainZ).

RESULTS

Infants with BPD had lower gestational age and higher male predominance (25 ± 1 weeks, 70%) compared with non-BPD infants (26 ± 1 weeks, 30%, all p ≤ 0.03), but similar birth weight (704 ± 195 vs. 796 ± 167 g, p = 0.1). During active sleep, infants with BPD had wider span voltage (p = 0.03), higher lower border voltage (p < 0.03), as well as less periods of quiet sleep per hour (p < 0.01) compared with non-BPD infants. These differences persisted after adjustment for covariates.

CONCLUSION

Infants with BPD have small but significant differences in their aEEG tracings compared with infants without BPD at 36 weeks. Further study of infants with BPD using aEEG appears justified to determine whether aEEG variables correlate with neurodevelopmental outcome.

摘要

目的

评估患有和不患有支气管肺发育不良（BPD）的婴儿振幅整合脑电图（aEEG）记录的差异。

方法

这是一项对出生时≤27 周的婴儿进行的横断面研究，其中患有（n=17）或未患有 BPD（n=17）。使用 BrainZ BRM3 监测仪在 36（0）-36（6）周龄时进行 6 小时的 aEEG 描记。使用离线软件 Analyze（BrainZ）评估跨脑通道。

结果

与非 BPD 婴儿（26±1 周，30%）相比，患有 BPD 的婴儿胎龄更低，男性比例更高（25±1 周，70%，所有 p≤0.03），但出生体重相似（704±195 与 796±167 g，p=0.1）。在活跃睡眠期间，与非 BPD 婴儿相比，患有 BPD 的婴儿的电压跨度更宽（p=0.03）、下边界电压更高（p<0.03）以及每小时安静睡眠时间更少（p<0.01）。这些差异在调整协变量后仍然存在。