School and Graduate Institute of Physical Therapy, National Taiwan University College of Medicine, Taipei, Taiwan.
Pediatr Pulmonol. 2010 Feb;45(2):165-73. doi: 10.1002/ppul.21171.
Oral feeding has been reported to compromise breathing among preterm infants with bronchopulmonary dysplasia (BPD) during hospitalization or shortly after discharge. However, limited information was available concerning whether preterm infants with BPD remain vulnerable to feeding and growth insufficiency after a longer term of follow-up. The purpose of this study was therefore to examine the effect of severity of BPD on pulse oxygen saturation (SpO(2)) during feeding and growth in very low birth weight (VLBW) preterm infants during infancy. Seventy-two preterm infants with VLBW and 15 term infants were prospectively examined their growth and SpO(2) during feeding at 2, 4, and 6 months of corrected age. The severity of BPD was graded in VLBW infants according to the American National Institutes of Health consensus definition. In comparison to VLBW infants with mild BPD and term infants, VLBW infants with severe BPD showed significantly lower mean levels of SpO(2) during feeding at 2-6 months corrected age (P < 0.05). Those with severe BPD further exhibited higher rates of growth delay (weight < 10th percentile) throughout the study period. Among VLBW infants, severe BPD had an adverse relation with subsequent weight measures after adjustment for medical and demographic confounding variables (beta = -904 g, P = 0.03). The consensus BPD definition is useful to identify those preterm infants who are at greater risk of feeding desaturation and growth delay during infancy and close monitoring of SpO(2) during feeding should be advised.
有报道称，患有支气管肺发育不良（BPD）的早产儿在住院期间或出院后不久进行口喂养时会出现呼吸问题。然而，关于患有 BPD 的早产儿在更长时间的随访后是否仍然容易出现喂养和生长不足的问题，相关信息有限。因此，本研究旨在检查 BPD 的严重程度对极低出生体重（VLBW）早产儿在婴儿期喂养期间脉搏血氧饱和度（SpO₂）和生长的影响。72 名患有 VLBW 的早产儿和 15 名足月婴儿前瞻性地检查了他们在纠正年龄 2、4 和 6 个月时的生长和喂养期间的 SpO₂。根据美国国立卫生研究院共识定义，将 VLBW 婴儿的 BPD 严重程度分级。与患有轻度 BPD 的 VLBW 婴儿和足月婴儿相比，患有严重 BPD 的 VLBW 婴儿在纠正年龄 2-6 个月期间喂养时的平均 SpO₂水平明显较低（P < 0.05）。那些患有严重 BPD 的婴儿在整个研究期间进一步表现出更高的生长迟缓率（体重<第 10 百分位数）。在 VLBW 婴儿中，在调整了医学和人口统计学混杂变量后，严重 BPD 与随后的体重测量值呈负相关（β=-904g，P=0.03）。共识 BPD 定义可用于识别那些在婴儿期喂养时出现血氧饱和度降低和生长迟缓风险更高的早产儿，应建议在喂养期间密切监测 SpO₂。
