Clinical Trials Research Unit, London School of Hygiene and Tropical Medicine, UK.
Lancet. 2011 Jul 2;378(9785):49-55. doi: 10.1016/S0140-6736(11)60701-0.
Smoking cessation programmes delivered via mobile phone text messaging show increases in self-reported quitting in the short term. We assessed the effect of an automated smoking cessation programme delivered via mobile phone text messaging on continuous abstinence, which was biochemically verified at 6 months.
In this single-blind, randomised trial, undertaken in the UK, smokers willing to make a quit attempt were randomly allocated, using an independent telephone randomisation system, to a mobile phone text messaging smoking cessation programme (txt2stop), comprising motivational messages and behavioural-change support, or to a control group that received text messages unrelated to quitting. The system automatically generated intervention or control group texts according to the allocation. Outcome assessors were masked to treatment allocation. The primary outcome was self-reported continuous smoking abstinence, biochemically verified at 6 months. All analyses were by intention to treat. This study is registered, number ISRCTN 80978588.
We assessed 11,914 participants for eligibility. 5800 participants were randomised, of whom 2915 smokers were allocated to the txt2stop intervention and 2885 were allocated to the control group; eight were excluded because they were randomised more than once. Primary outcome data were available for 5524 (95%) participants. Biochemically verified continuous abstinence at 6 months was significantly increased in the txt2stop group (10·7% txt2stop vs 4·9% control, relative risk [RR] 2·20, 95% CI 1·80-2·68; p<0·0001). Similar results were obtained when participants that were lost to follow-up were treated as smokers (268 [9%] of 2911 txt2stop vs 124 [4%] of 2881 control [RR 2·14, 95% CI 1·74-2·63; p<0·0001]), and when they were excluded (268 [10%] of 2735 txt2stop vs 124 [4%] of 2789 control [2·20, 1·79-2·71; p<0·0001]). No significant heterogeneity was shown in any of the prespecified subgroups.
The txt2stop smoking cessation programme significantly improved smoking cessation rates at 6 months and should be considered for inclusion in smoking cessation services.
UK Medical Research Council, Primary Care Research Networks.
通过手机短信传递的戒烟计划显示，短期内心肺科文献的自我报告戒烟率有所增加。我们评估了通过手机短信传递的自动戒烟计划对 6 个月时生物化学验证的持续戒烟的影响。
这是一项在英国进行的单盲、随机试验，愿意戒烟的吸烟者被随机分配到手机短信戒烟计划（txt2stop）组或对照组，通过独立的电话随机分配系统进行。txt2stop 组包含动机性信息和行为改变支持，对照组则收到与戒烟无关的短信。系统根据分配自动生成干预或对照组的短信。结果评估者对治疗分配情况不知情。主要结局为 6 个月时生物化学验证的自我报告持续戒烟。所有分析均采用意向治疗。本研究已注册，编号 ISRCTN80978588。
我们评估了 11914 名参与者的合格性。5800 名参与者被随机分配，其中 2915 名吸烟者被分配到 txt2stop 干预组，2885 名被分配到对照组；8 名因多次被随机分配而被排除。5524 名（95%）参与者提供了主要结局数据。6 个月时生物化学验证的持续戒烟率在 txt2stop 组显著增加（10.7%的 txt2stop 组 vs 4.9%的对照组，相对风险[RR]2.20，95%置信区间[CI]1.80-2.68；p<0.0001）。当将随访丢失的参与者视为吸烟者（2911 名 txt2stop 组中 268 名[9%] vs 2881 名对照组中 124 名[4%]；RR2.14，95%CI1.74-2.63；p<0.0001）或被排除（2735 名 txt2stop 组中 268 名[10%] vs 2789 名对照组中 124 名[4%]；RR2.20，1.79-2.71；p<0.0001）时，也得到了类似的结果。在所有预先指定的亚组中均未显示出显著的异质性。
txt2stop 戒烟计划显著提高了 6 个月时的戒烟率，应考虑将其纳入戒烟服务中。
英国医学研究理事会，初级保健研究网络。
