Cowen P J
MRC Unit of Clinical Pharmacology, Littlemore Hospital, Oxford, England.
Int Clin Psychopharmacol. 1990 Jul;5 Suppl 3:45-55.
Repeated administration of antidepressant drugs to rodents produces adaptive changes in noradrenaline and 5-hydroxytryptamine pathways in the brain. A decrease in cortical beta-adrenoceptor binding is seen following most antidepressant treatments and is thought by some to be of importance in the therapeutic action of antidepressants; however, it seems equally plausible that this change simply reflects a homeostatic response to increased noradrenergic transmission. Another effect common to many different antidepressant treatments is an increase in neurotransmission through post-synaptic 5-HT1 receptors in some brain regions. 5-HT neuroendocrine studies suggest that this change also occurs in the human brain. Further investigations are required to assess whether alterations in 5-HT neurotransmissions are important in the therapeutic action of antidepressant treatment.
对啮齿动物反复给予抗抑郁药物会使大脑中的去甲肾上腺素和5-羟色胺途径产生适应性变化。大多数抗抑郁治疗后会出现皮质β-肾上腺素能受体结合减少的情况，一些人认为这在抗抑郁药的治疗作用中具有重要意义；然而，这种变化仅仅反映了对去甲肾上腺素能传递增加的一种稳态反应，这似乎同样合理。许多不同抗抑郁治疗的另一个共同作用是，某些脑区通过突触后5-HT1受体的神经传递增加。5-羟色胺神经内分泌研究表明，这种变化在人类大脑中也会发生。需要进一步研究来评估5-羟色胺神经传递的改变在抗抑郁治疗的治疗作用中是否重要。
