National Centre for the Replacement, Refinement and Reduction of Animals in Research, 20 Park Crescent, London, W1B 1AL, UK.
Drug Discov Today. 2011 Aug;16(15-16):659-70. doi: 10.1016/j.drudis.2011.05.014. Epub 2011 Jun 23.
Asthma remains an area of considerable unmet medical need. Few new drugs have made it to the clinic during the past 50 years, with many that perform well in preclinical animal models of asthma, failing in humans owing to lack of safety and efficacy. The failure to translate promising drug candidates from animal models to humans has led to questions about the utility of in vivo studies and to demand for more predictive models and tools based on the latest technologies. Following a workshop with experts from academia and the pharmaceutical industry, we suggest here a disease modelling framework designed to better understand human asthma, and accelerate the development of safe and efficacious new asthma drugs that go beyond symptomatic relief.
哮喘仍然是一个存在大量未满足医疗需求的领域。在过去的 50 年中，很少有新药进入临床，许多在哮喘的临床前动物模型中表现良好的药物由于安全性和疗效问题而在人体中失败。将有前途的候选药物从动物模型转化为人体的失败导致了对体内研究的实用性的质疑，并要求基于最新技术的更具预测性的模型和工具。在与学术界和制药行业的专家进行研讨会后，我们在这里提出了一种疾病建模框架，旨在更好地了解人类哮喘，并加速开发安全有效的新型哮喘药物，超越症状缓解。
