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GLP-1-based therapies: the dilemma of uncertainty.

作者信息

Spranger Joachim, Gundert-Remy Ursula, Stammschulte Thomas

出版信息

Gastroenterology. 2011 Jul;141(1):20-3. doi: 10.1053/j.gastro.2011.05.019.

DOI:10.1053/j.gastro.2011.05.019
PMID:21723985
Abstract
摘要

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GLP-1-based therapies: the dilemma of uncertainty.基于胰高血糖素样肽-1的疗法:不确定性的困境。
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The potential risks of pancreatitis and pancreatic cancer with GLP-1-based therapies are far outweighed by the proven and potential (cardiovascular) benefits.GLP-1 类药物治疗相关的胰腺炎和胰腺癌风险远远低于其已证实和潜在的(心血管)获益。
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The incretin system: glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors in type 2 diabetes.肠促胰岛素系统:2型糖尿病中的胰高血糖素样肽-1受体激动剂和二肽基肽酶-4抑制剂
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Two drugs for type 2 diabetes seem to raise risk of acute pancreatitis, study shows.研究表明,两种用于治疗2型糖尿病的药物似乎会增加急性胰腺炎的风险。
BMJ. 2013 Feb 27;346:f1304. doi: 10.1136/bmj.f1304.

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胰高血糖素样肽-1 受体激动剂与胰腺癌风险:一项使用 FDA 不良事件报告系统和文献可视化分析的药物警戒研究。
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The Relationship Between Dipeptidyl Peptidase-4 Inhibitor Usage and Asymptomatic Amylase Lipase Increment in Type 2 Diabetes Mellitus Patients.2型糖尿病患者使用二肽基肽酶-4抑制剂与无症状淀粉酶脂肪酶升高之间的关系
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