Faden H, Modlin J F, Thoms M L, McBean A M, Ferdon M B, Ogra P L
Department of Pediatrics, State University of New York School of Medicine, Buffalo.
J Infect Dis. 1990 Dec;162(6):1291-7. doi: 10.1093/infdis/162.6.1291.
Serum neutralizing, nasopharyngeal neutralizing, and IgA antibodies were determined in 123 infants immunized with one of four schedules containing live oral vaccine (OPV), inactivated vaccine (IPV), or combinations of the two trivalent poliovirus vaccines: OPV-OPV-OPV, IPV-IPV-IPV, IPV-OPV-OPV, or IPV-IPV-OPV. Nearly 100% of individuals formed serum neutralizing antibodies. The highest geometric mean titer (GMT) of antibody to polioviruses 1, 2, and 3 occurred in groups IPV-IPV-OPV, IPV-OPV-OPV, and IPV-IPV-IPV, respectively. Local neutralizing and IgA antibody responses were detected in 41%-88% and 75%-100%, respectively. Peak GMT of nasopharyngeal antibodies differed minimally between immunization groups. The data suggest that incorporation of at least one dose of IPV at the start of the immunization schedule tends to increase systemic as well as local antibody production.
对123名婴儿进行了血清中和抗体、鼻咽中和抗体及IgA抗体检测，这些婴儿按照四种免疫程序之一进行了免疫接种，这四种程序包含口服活疫苗（OPV）、灭活疫苗（IPV）或两种三价脊髓灰质炎疫苗的组合：OPV-OPV-OPV、IPV-IPV-IPV、IPV-OPV-OPV或IPV-IPV-OPV。近100%的个体产生了血清中和抗体。脊髓灰质炎病毒1型、2型和3型抗体的最高几何平均滴度（GMT）分别出现在IPV-IPV-OPV组、IPV-OPV-OPV组和IPV-IPV-IPV组。分别在41%-88%和75%-100%的个体中检测到了局部中和抗体及IgA抗体反应。各免疫组之间鼻咽抗体的GMT峰值差异极小。数据表明，在免疫程序开始时纳入至少一剂IPV往往会增加全身及局部抗体的产生。
