Shimano S, Fukushima M, Sawada Y
Department of Obstetrics and Gynecology, Sapporo Medical College.
Nihon Sanka Fujinka Gakkai Zasshi. 1990 Oct;42(10):1331-8.
HPV DNA was detected in 11% (4/36) of cervical squamous metaplasia, 43% (6/14) of mild dysplasia, 39% (7/18) of moderate dysplasia, 50% (7/14) of severe dysplasia and 50% (7/14) of CIS. The incidence of HPV16 DNA increased with the severity of dysplasia through CIS. It was distributed almost evenly in the nuclei of the total epithelial layers in severe dysplasia and CIS. Especially in CIS, HPV DNA was found significantly in the nuclei of both basal and parabasal cells, suggesting the possibility of involvement in the carcinogenesis of cervical cancer. The presence of HPV DNA in squamous metaplasia (36 cases) was investigated in three different pathological situations. Group 1 was squamous metaplasia in squamo-columnar junction; Group 2 in the polyp; and Group 3 accompanied by dysplasia or CIS. HPV DNA was positive only in squamous metaplasias with polyps. In these HPV DNA positive cases, HPV DNA was distributed not only in the metaplastic lesion, but also in the adjacent stromal lesion.
在11%（4/36）的宫颈鳞状化生、43%（6/14）的轻度发育异常、39%（7/18）的中度发育异常、50%（7/14）的重度发育异常和50%（7/14）的原位癌中检测到HPV DNA。HPV16 DNA的发生率随着发育异常至原位癌的严重程度增加而升高。在重度发育异常和原位癌中，它几乎均匀地分布在整个上皮层的细胞核中。特别是在原位癌中，在基底细胞和副基底细胞的细胞核中均显著发现HPV DNA，提示其可能参与宫颈癌的致癌过程。在三种不同病理情况下研究了36例鳞状化生中HPV DNA的存在情况。第1组为鳞柱交界部的鳞状化生；第2组为息肉中的鳞状化生；第3组伴有发育异常或原位癌。仅在伴有息肉的鳞状化生中HPV DNA呈阳性。在这些HPV DNA阳性病例中，HPV DNA不仅分布于化生病变中，还分布于相邻的间质病变中。
