Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida 33136, USA.
Ophthalmology. 2011 Dec;118(12):2434-41. doi: 10.1016/j.ophtha.2011.05.008. Epub 2011 Jul 2.
To characterize the natural history of drusen using spectral-domain optical coherence tomography (SD-OCT) imaging of eyes from patients with nonexudative age-related macular degeneration (AMD).
Prospective, longitudinal, natural history study.
We included 143 eyes of 100 patients with at least 6 months of follow-up.
Patients with drusen secondary to nonexudative AMD were scanned using the Cirrus SD-OCT instrument. Eyes were imaged using the 200 × 200 A-scan raster pattern contained within a 6 × 6 mm area. Custom software was used to quantify volumetric changes in drusen over a period of ≥ 6 months and for as long as 24 months. Drusen volume and drusen area were measured within circular regions centered at the fovea having diameters of 3 and 5 mm. The measurements were analyzed using a suitable scale transformation. For drusen volume, a cube root transformation strategy was used.
Change in drusen volume and area over time.
We analyzed 143 eyes of 100 patients with 69 eyes followed for 6 months, 106 eyes followed for 12 months, 48 eyes followed for 18 months, and 48 eyes followed for 24 months. The 3 mm circle baseline drusen volume ranged from 0.0009 to 0.7479 mm(3) or 0.10 to 0.91 mm using the cube root scale. On average, drusen volume and drusen area increased over time with the magnitude of the increase dependent on the length of follow-up (P = 0.001, 3 mm circle). In the eyes with a decrease in drusen volume, the magnitude of this decrease was dependent on the baseline drusen volume (P = 0.001, 3 mm circle) and independent of the follow-up interval. After 12 months, drusen volume increased in 48% of eyes, remained stable in 40%, and decreased in 12%.
Imaging with SD-OCT revealed a dynamic, undulating growth pattern for drusen with a tendency for drusen to increase in volume and area over time. An appreciation of the quantitative changes in drusen volume over time using SD-OCT imaging provides a novel strategy for following normal disease progression and for identifying novel clinical trial end points to be used when investigating therapies for the treatment of nonexudative AMD.
FINANCIAL DISCLOSURE(S): Proprietary or commercial disclosure may be found after the references.
使用频域光相干断层扫描（SD-OCT）对非渗出性年龄相关性黄斑变性（AMD）患者的眼部进行成像，以描述玻璃膜疣的自然史。
前瞻性、纵向、自然史研究。
我们纳入了至少有 6 个月随访的 100 名患者的 143 只眼。
使用 Cirrus SD-OCT 仪器对继发于非渗出性 AMD 的玻璃膜疣患者进行扫描。使用包含在 6×6mm 区域内的 200×200A 扫描光栅图案对眼睛进行成像。使用定制软件在至少 6 个月且长达 24 个月的时间内定量评估玻璃膜疣的体积变化。在以黄斑为中心的直径为 3mm 和 5mm 的圆形区域内测量玻璃膜疣的体积和面积。使用适当的比例转换分析测量值。对于玻璃膜疣体积，采用立方根转换策略。
随时间变化的玻璃膜疣体积和面积变化。
我们分析了 100 名患者的 143 只眼，其中 69 只眼随访 6 个月，106 只眼随访 12 个月，48 只眼随访 18 个月，48 只眼随访 24 个月。3mm 圆基线玻璃膜疣体积范围为 0.0009 至 0.7479mm³（使用立方根刻度为 0.10 至 0.91mm）。平均而言，玻璃膜疣体积和面积随时间增加，增加的幅度取决于随访时间（P=0.001，3mm 圆）。在玻璃膜疣体积减小的眼中，这种减小的幅度取决于基线玻璃膜疣体积（P=0.001，3mm 圆），与随访间隔无关。12 个月后，48%的眼玻璃膜疣体积增加，40%的眼玻璃膜疣体积保持稳定，12%的眼玻璃膜疣体积减小。
SD-OCT 成像显示玻璃膜疣具有动态、波动的生长模式，其体积和面积随时间呈增加趋势。使用 SD-OCT 成像评估玻璃膜疣体积随时间的定量变化为了解正常疾病进展提供了一种新策略，并为识别治疗非渗出性 AMD 的新临床试验终点提供了一种新策略。
参考文献之后可能有专有或商业披露。
