抗人肿瘤坏死因子受体单克隆抗体对细胞功能的结合与调节
Binding and regulation of cellular functions by monoclonal antibodies against human tumor necrosis factor receptors.
作者信息
Shalaby M R, Sundan A, Loetscher H, Brockhaus M, Lesslauer W, Espevik T
机构信息
Institute of Cancer Research, University of Trondheim, Norway.
出版信息
J Exp Med. 1990 Nov 1;172(5):1517-20. doi: 10.1084/jem.172.5.1517.
Abstract
The present study was undertaken to further characterize the interaction of monoclonal antibodies (mAbs) against tumor necrosis factor (TNF) receptors with different targets, and to assess their ability to influence TNF effects on U937 and human endothelial cell (HEC) functions. Actions of recombinant TNF-alpha on U937 and HEC were effectively inhibited by Htr-5 and Utr-1, and to a greater extent by a combination of both mAbs. These observations indicate that TNF interaction with antigenically different components of membrane receptors (p55 and p75) represents a crucial step in transduction of signals for TNF toxicity against U937 and TNF activation of HEC functions.
摘要
本研究旨在进一步表征抗肿瘤坏死因子（TNF）受体的单克隆抗体（mAb）与不同靶点的相互作用，并评估其影响TNF对U937和人内皮细胞（HEC）功能作用的能力。重组TNF-α对U937和HEC的作用被Htr-5和Utr-1有效抑制，两种mAb联合使用时抑制作用更强。这些观察结果表明，TNF与膜受体（p55和p75）抗原性不同的成分相互作用是TNF对U937产生毒性信号转导以及TNF激活HEC功能的关键步骤。
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