人肿瘤坏死因子：前体结构、表达及其与淋巴毒素的同源性。
Human tumour necrosis factor: precursor structure, expression and homology to lymphotoxin.
作者信息
Pennica D, Nedwin G E, Hayflick J S, Seeburg P H, Derynck R, Palladino M A, Kohr W J, Aggarwal B B, Goeddel D V
出版信息
Nature. 1984;312(5996):724-9. doi: 10.1038/312724a0.
DOI:10.1038/312724a0
PMID:6392892
Abstract
Human tumour necrosis factor has about 30% homology in its amino acid sequence with lymphotoxin, a lymphokine that has similar biological properties. Recombinant tumour necrosis factor can be obtained by expression of its complementary DNA in Escherichia coli and induces the haemorrhagic necrosis of transplanted methylcholanthrene-induced sarcomas in syngeneic mice.
摘要
人肿瘤坏死因子的氨基酸序列与淋巴毒素有大约30%的同源性，淋巴毒素是一种具有相似生物学特性的淋巴因子。重组肿瘤坏死因子可通过在大肠杆菌中表达其互补DNA获得，并能诱导同基因小鼠体内移植的甲基胆蒽诱导肉瘤发生出血性坏死。
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