Section for Reproductive Medicine, Department of Gynecology, Oslo University Hospital, Oslo, Norway.
Hum Reprod. 2011 Sep;26(9):2499-504. doi: 10.1093/humrep/der214. Epub 2011 Jun 30.
Subfertility due to chronic anovulation is common in women with polycystic ovary syndrome (PCOS) and is often treated with IVF. Women with PCOS have an increased ovarian follicle and oocyte count, increased ovarian reserve and/or a slower rate of follicle atresia. If so, one would expect women with PCOS to display a delayed reduction in fertility with advancing age as compared with eumenorrheic women.
To test this hypothesis, we compared oocyte count and live birth rates among two groups undergoing IVF, 500 women with PCOS and 500 eumenorrheic women with infertility due to tubal factor only.
Across the age range of 22-41 years, oocyte count and live birth rates remained stable in women with PCOS. In the eumenorrheic comparison group, these parameters decreased significantly with age.
Women with PCOS display sustained fertility with advancing age as compared with infertile eumenorrheic women.
多囊卵巢综合征（PCOS）患者常因慢性排卵障碍而导致不孕，常采用体外受精（IVF）治疗。PCOS 患者的卵巢卵泡和卵母细胞数量增加，卵巢储备增加和/或卵泡闭锁速度较慢。如果是这样，人们会预期 PCOS 患者的生育能力随着年龄的增长而逐渐下降，与月经正常的不孕女性相比，这种下降会有所延迟。
为了验证这一假说，我们比较了两组接受 IVF 的患者的卵母细胞计数和活产率，一组是 500 名患有 PCOS 的患者，另一组是 500 名因输卵管因素导致不孕的月经正常的患者。
在 22-41 岁的年龄范围内，PCOS 患者的卵母细胞计数和活产率保持稳定。在月经正常的对照组中，这些参数随年龄显著下降。
与月经正常的不孕女性相比，PCOS 患者的生育能力随着年龄的增长而保持稳定。
