Laboratory of Hemodynamics and Cardiovascular Technology, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.
Am J Physiol Heart Circ Physiol. 2011 Oct;301(4):H1286-301. doi: 10.1152/ajpheart.00570.2010. Epub 2011 Jul 1.
In the present report, a constituent-based theoretical model of age-related changes in geometry and mechanical properties of conduit arteries is proposed. The model was based on the premise that given the time course of the load on an artery and the accumulation of advanced glycation end-products in the arterial tissue, the initial geometric dimensions and properties of the arterial tissue can be predicted by a solution of a boundary value problem for the governing equations that follow from finite elasticity, structure-based constitutive modeling within the constrained mixture theory, continuum damage theory, and global growth approach for stress-induced structure-based remodeling. An illustrative example of the age-related changes in geometry, structure, composition, and mechanical properties of a human thoracic aorta is considered. Model predictions were in good qualitative agreement with available experimental data in the literature. Limitations and perspectives for refining the model are discussed.
在本报告中，提出了一种基于组成的理论模型，用于描述导管动脉的几何形状和力学性能随年龄的变化。该模型基于以下前提：给定动脉上的载荷随时间的变化以及动脉组织中晚期糖基化终产物的积累，可以通过求解由有限弹性、基于结构的本构建模、约束混合物理论、连续损伤理论和基于应力的结构重塑的整体生长方法得出的控制方程的边值问题，预测动脉组织的初始几何尺寸和特性。考虑了人体胸主动脉的几何形状、结构、组成和力学性能随年龄变化的一个说明性示例。模型预测与文献中可用的实验数据具有良好的定性一致性。讨论了限制因素和改进模型的观点。
