脑动静脉畸形的发病机制：一种损伤反应模式。
Brain arteriovenous malformation pathogenesis: a response-to-injury paradigm.
作者信息
Kim Helen, Su Hua, Weinsheimer Shantel, Pawlikowska Ludmila, Young William L
机构信息
Center for Cerebrovascular Research, Department of Anesthesia and Perioperative Care, University of California, San Francisco, CA 94110, USA.
出版信息
Acta Neurochir Suppl. 2011;111:83-92. doi: 10.1007/978-3-7091-0693-8_14.
Abstract
Brain arteriovenous malformations (AVMs) are a rare but important cause of intracranial hemorrhage (ICH) in young adults. In this paper, we review both human and animal studies of brain AVM, focusing on the: (1) natural history of AVM hemorrhage, (2) genetic and expression studies of AVM susceptibility and hemorrhage, and (3) strategies for development of a brain AVM model in adult mice. These data target various mechanisms that must act in concert to regulate normal angiogenic response to injury. Based on the various lines of evidence reviewed in this paper, we propose a "response-to-injury" model of brain AVM pathogenesis.
摘要
脑动静脉畸形（AVM）是年轻成年人颅内出血（ICH）的一个罕见但重要的病因。在本文中，我们回顾了关于脑AVM的人体和动物研究，重点关注：（1）AVM出血的自然病史，（2）AVM易感性和出血的遗传及表达研究，以及（3）成年小鼠脑AVM模型的开发策略。这些数据针对的是各种必须协同作用以调节对损伤的正常血管生成反应的机制。基于本文所回顾的各种证据，我们提出了一种脑AVM发病机制的“损伤反应”模型。
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