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新型恶唑烷衍生物的合成、表征及抗高血糖活性研究。

Synthesis, characterization, and antihyperglycemic activity of novel oxazolidine derivatives.

机构信息

Department of Pharmaceutical Chemistry, Srinivas College of Pharmacy, Valachil, Mangalore, 574 143 Karnataka, India.

出版信息

Arch Pharm Res. 2011 Jun;34(6):887-91. doi: 10.1007/s12272-011-0604-3. Epub 2011 Jul 2.

DOI:10.1007/s12272-011-0604-3
PMID:21725808
Abstract

A number of compounds have been prepared in order to improve pharmacological roles of antihyperglycemic activity. In the present paper, a series of 3-benzyl-2-(4'-substituted phenyl)-4(5H)-(4″-nitrophenyl amino)-1,3-oxazolidines (6a-e) were tested against hyperglycemia. Their antihyperglycemic activity was evaluated by streptozotocin (STZ) and sucrose-loaded (SLM) models. Compounds 6a, b, c, d, and e displayed significant reductions in blood glucose in the streptozotocin and sucrose loaded rat models. The purity of the synthesized compounds was characterized by means of IR, (1)H-NMR, mass spectral and elemental analysis.

摘要

为了提高抗高血糖活性的药理作用，已经制备了许多化合物。在本文中，我们测试了一系列 3-苄基-2-(4'-取代苯基)-4(5H)-(4″-硝基苯氨基)-1,3-恶唑烷 (6a-e) 对高血糖的作用。通过链脲佐菌素 (STZ) 和蔗糖负荷 (SLM) 模型评价它们的抗高血糖活性。化合物 6a、b、c、d 和 e 在链脲佐菌素和蔗糖负荷大鼠模型中显著降低血糖。通过红外光谱 (IR)、(1)H-NMR、质谱和元素分析来表征合成化合物的纯度。

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